Trifluoperazine Pharmacology


About Trifluoperazine
First-Generation Antipsychotic, piperazine-phenothiazine derivative, Typical Antipsychotic, antiemetic,antimanic.
Mechanism of Action of Trifluoperazine
Antipsychotic action: Trifluoperazine binds to the dopamine receptor (D1, D2, D3 &D4).It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. Peripherally and centrally it acts as a competitive Dopamine antagonist. Trifluoperazine also produces alpha adrenergic blocking activity and anticholinergic activity. It also produces weak H1 antihistaminic activity and anti serotonin activity.
Antiemetic activity: Antiemetic activity is by blocking dopamine receptor (D2 receptor) in the Chemoreceptor trigger zone (CTZ)
Pharmacokinets of Trifluoperazine
Absorption: It is absorbed after oral administration.
Distribution: It is distributed widely in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: It is excreted mainly through urine. Small amount of drug is excreted through faeces and breast milk.
Onset of Action for Trifluoperazine
30 - 60 minutes
Duration of Action for Trifluoperazine
4- 6 hours
Half Life of Trifluoperazine
3 - 22 hours
Side Effects of Trifluoperazine
1. Tardive dyskinesia
2. Extrapyramidal reactions
3. Drowsiness
4. Sedation
5. Dizziness
6. Hypotension
7. Dry mouth
8. Constipation
9. Blurred vision
10. Agranulocytosis
11. Photosensitivity
12. Insomnia
13. Weight gain
14. Cholestatic jaundice
Contra-indications of Trifluoperazine
1. Hypersensitivity to Trifluoperazine and other Phenothiazines
2. Comatose
3. Blood dyscrasias
4. Patient taking antidepressants
5. Liver damage
Special Precautions while taking Trifluoperazine
1. Renal impairment
2. Hepatic impairment
3. Cardiovascular disease
4. Pheochromocytoma
5. Hypocalcaemia
6. Epilepsy
7. Cholestatic jaundice
8. Patient exposed to extreme heat or cold or phosphorus insecticides
9. Ceribrovascular disorder
10. Patient on ECT
11. Reaction to Insulin
12. Prostatic hyperplasia
13. Glaucoma
14. Peptic ulcer, slowly withdraw the drug with caution
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Below 6years : Contraindicated
Indications for Trifluoperazine
1. Psychoses
2. Schizophrenia
3. Antiemetic
4. Anxiety
5. Behavioural disturbances
6. Mania
Interactions for Trifluoperazine
Alcohol: CNS depression, extra-pyramidal reactions.
Almunium Salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after chlorpromazine.
Anticholinergics: Decrease efficacy and increase the anticholinergic side effects of chlorpromazine.
Barbiturates: Decreases efficacy.
Barbiturate anaesthetics: Increase frequency and severity of neuromuscular excitation and hypotension.
Bromocriptine: Efficacy decreased by chlorpromazine.
Charcoal: Prevents absorption of chlorpromazine.
Epinephrine, Norepinephrine: Pressor effect decreased, peripheral vasoconstrictive effect antagonised.
Lithium: Disorientation, unconsciousness and extra-pyramidal symptoms.
Meperidine: Excessive sedation and hypotension.
TCAs: Serum concentration increased by chlorpromazine.
Valproic acid: Efficacy potentiated.
Propranolol: Increased plasma levels of both drugs.
MAOIs: Additive orthostatic hypotensive effect.
Lab. Tests: Pregnancy tests: False positive results.
Plasma bound iodine (PBI): Increase in PBI occurs.
Typical Dosage for Trifluoperazine
Psychoses, Schizophrenia
Out patients: 2 - 4 mg / day in 2 divided doses. Dose can be increased depending on the severity of the disease.
Inpatients: 4 - 10 mg / day in 2 divided doses. Dose can be gradually increased up to 40 mg / day.
Antiemetic, Anxiety: 1 - 2 mg twice daily. Dose can be increased up to 6 mg / day in some case.

Psychoses, Schizophrenia: 1 - 2 mg / day. Dose can be gradually increased up to 15 mg / day.
Schedule of Trifluoperazine
Storage Requirements for Trifluoperazine
The drug should be kept at 25 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Trifluoperazine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Trifluoperazine
Give supportive measures and treatment. Gastric lavage has to be done. Activated charcoal can be given to reduce the absorption of the drug. Hypotension can be treated with IV fluids, seizure with Diazepam or Barbiturates, arrhythmia with Phenytoin and extra pyramidal reactions with Benztropine.

Home Delivery for Trifluoperazine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trifluoperazine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trifluoperazine and other medicines and health products. Home delivery services for trifluoperazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take trifluoperazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trifluoperazine before they complete the sale. You can get this information while placing the order for trifluoperazine with the pharmacy.

Trifluoperazine is a generic medicine name and there are several brands available for it. Some of the brands for trifluoperazine might be better known than trifluoperazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trifluoperazine in stock, you can ask for one of the branded alternatives for trifluoperazine.