Risperidone Pharmacology


About Risperidone
Second-Generation Antipsychotic, benzisoxazole derivative, Antimanic, Atypical Antipsychotic.
Mechanism of Action of Risperidone
Risperidone exerts its antipsychotic activity by blocking Dopamine and Serotonin (5HT2) receptors. The drug has antagonistic action on alpha adrenergic and histaminergic receptors. These produce an increase in neurotransmitters concentration and thereby antipsychotic action.
Pharmacokinets of Risperidone
Absorption: It is well absorbed after oral administration.
Distribution: It is distributed in the body in protein bound form.
Metabolism: Risperidone is extensively metabolised in the liver.
Excretion: Risperidone and its metabolites are excreted primarily in urine. Small amount excreted in faeces.
Onset of Action for Risperidone
2 - 3 days
Duration of Action for Risperidone
2 days
Half Life of Risperidone
20 hours
Side Effects of Risperidone
1. Orthostatic hypotension
2. Dizziness
3. Insomnia
4. Somnolence
5. Agitation
6. Anxiety
7. Nausea
8. Headache
9. Rhinitis
10. Constipation
11. Dyspepsia
12. Abdominal pain
13. Hyperprolactinemia
14. Neuroleptic malignant syndrome
15. Tardive dyskinesia
Contra-indications of Risperidone
1. Hypersensitivity to Risperidone
Special Precautions while taking Risperidone
1. Renal impairment
2. Hepatic impairment
3. Tachycardia
4. Orthostatic hypotension
5. Prolonged QT interval
6. History of seizure
7. Patient exposed to extreme heat and those with concomitant systemic illness
8. Dehydration
9. Hyperglycemia
10. Alcoholics
11. Discontinue the drug if Tardive dyskinesia occurs
12. Patient should be cautioned while driving vehicle, operating machine and activities requiring mental alertness or judgment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Risperidone
Interactions for Risperidone
Levodopa : Efficacy of levodopa and dopamine agonists reduced.
Carbamazepine : Chronic administration of carbamazepine may decrease it`s efficacy.
Clozapine : Chronic administration of clozapine may enhance it`s efficacy.
Typical Dosage for Risperidone
Adult: 2 mg / day in 2 divided doses. Dose is increased by 2mg every day up to 6 mg / day.
Maintenance dose: 4 - 6 mg / day in 2 divided doses
Schedule of Risperidone
Storage Requirements for Risperidone
Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Risperidone
Take the missed dose as soon as noticed .If it is the time for next dose then skip the missed dose and take the next dose. Do not double the dose. Continue the regular schedule.
Effects of Overdose of Risperidone
Give supportive measures and treatment. Gastric lavage can be done to remove the drug from the body. Absorption of the drug can be reduced by administration of activated charcoal with laxative

Home Delivery for Risperidone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including risperidone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for risperidone and other medicines and health products. Home delivery services for risperidone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take risperidone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for risperidone before they complete the sale. You can get this information while placing the order for risperidone with the pharmacy.

Risperidone is a generic medicine name and there are several brands available for it. Some of the brands for risperidone might be better known than risperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have risperidone in stock, you can ask for one of the branded alternatives for risperidone.