Aripiprazole Pharmacology


About Aripiprazole
Second-Generation Atypical Antipsychotic, dopamine-serotonin stabilizer.
Mechanism of Action of Aripiprazole
The mechanism of action of Aripiprazole in the treatment of schizophrenia and bipolar disorder is unknown. The proposed mechanism is that Aripiprazole acts by combination of partial agonist activity at Dopamine (D2) and Serotonin (5HT1A) receptor and a potent antagonist at 5HT2A receptor.
Aripiprazole also has an antagonist activity at alpha1 adrenergic receptors.

Pharmacokinets of Aripiprazole
Absorption: Aripiprazole is well absorbed after oral administration. Distribution: Aripiprazole is extensively distributed in the body in protein bound form. Metabolism: It undergoes metabolism in the liver by hepatic enzymes. Excretion: Excreted mainly in faeces and small amount in urine also
Onset of Action for Aripiprazole
Duration of Action for Aripiprazole
Half Life of Aripiprazole
Side Effects of Aripiprazole
15.Blurred vision
16.Orthostatic hypotension
17.Dry mouth
Contra-indications of Aripiprazole
1. Hypersensitivity to Aripiprazole
Special Precautions while taking Aripiprazole
1.Renal impairment,
2.Hepatic impairment,
4.Myocardial infarction,
5.Ischemic heart disease,
6.Heart failure,
8.Patient with history of seizure or condition that lower the seizure threshold
9.Aspiration pneumonia
10.Patient should be cautioned about operating hazardous machinery
12.Alzheimer`s disease and dementia
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Aripiprazole
2.Bipolar disorder
Interactions for Aripiprazole
Carbamazepine: It cause an increase in Aripiprazole clearance and lower blood levels
Ketoconazole, Quinidine, Fluoxetine, Paroxetine: They inhibt Aripirazole elimination and cause increased blood levels.
Typical Dosage for Aripiprazole
Schizophrenia: 10 - 15 mg once daily .If needed dose can be increased after 2 weeks.
Bipolar disorder: 30 mg / day
Schedule of Aripiprazole
Storage Requirements for Aripiprazole
Store ithe drug at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Aripiprazole
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and continue the regular schedule. Do not double the dose.
Effects of Overdose of Aripiprazole
Give supportive measures and symptomatic treatment. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Aripiprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aripiprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aripiprazole and other medicines and health products. Home delivery services for aripiprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take aripiprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aripiprazole before they complete the sale. You can get this information while placing the order for aripiprazole with the pharmacy.

Aripiprazole is a generic medicine name and there are several brands available for it. Some of the brands for aripiprazole might be better known than aripiprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aripiprazole in stock, you can ask for one of the branded alternatives for aripiprazole.