Flupenthixol Pharmacology


About Flupenthixol
First-Generation Antipsychotic, a thioxanthene derivative, Typical Antipsychotic.
Mechanism of Action of Flupenthixol
Flupenthixol exerts its antipsychotic action by blocking post synaptic Dopamine receptor in the limbic system. It is a potent antagonist of D1&D2 receptors.
Flupenthixol is an alpha adrenergic receptor blocker and depresses many hypophyseal and hypothalamic hormones. It also blocks Prolactin inhibitory factor (PIF) and results in hyperprolactinemia.
Pharmacokinets of Flupenthixol
Absorption: Flupenthixol is slowly and incompletely absorbed after oral administration. Its bioavailability is only 50 % because it undergoes first pass metabolism. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver to inactive metabolites. Excretion: It is excreted mainly through faeces and small amount through urine.
Onset of Action for Flupenthixol
2 - 3 weeks
Duration of Action for Flupenthixol
1 - 3 days
Half Life of Flupenthixol
19 - 39 hours
Side Effects of Flupenthixol
Contra-indications of Flupenthixol
1.Tardive dyskinesia
2.Extrapyramidal reactions
7.Dry mouth
8.Weight gain
9.Sexual dysfunction
11.Epigastric distress
Special Precautions while taking Flupenthixol
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disease
4 Respiratory disorder
6.Bone marrow suppression
7.Prolactin dependent cancer
8.Caution while driving vehicle or operating machines or involve in any hazardous activities
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Flupenthixol
2.Depression with or without anxiety.
Interactions for Flupenthixol
Typical Dosage for Flupenthixol
Depression: 0.5 mg 2 times a day if needed dose can be increased to 2 mg / day after 1 week.
Maximum dose: 3 mg / day
Psychoses: 3 mg 2 times daily dose can be gradually increase to 18 mg / day if needed.
Test dose: 20 mg after 1 week 20 - 40mg and repeat it every 2 - 4 week. Adjust according to response.
Maximum dose: 400 mg /week
Schedule of Flupenthixol
Storage Requirements for Flupenthixol
Store at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children. Protect from heat and light.
Effects of Missed Dosage of Flupenthixol
Take the missed dose as soon as noticed. If it is the time to take the next dose then skip the missed dose and take that dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Flupenthixol
Give supportive measures and treatment.

Home Delivery for Flupenthixol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including flupenthixol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for flupenthixol and other medicines and health products. Home delivery services for flupenthixol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take flupenthixol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for flupenthixol before they complete the sale. You can get this information while placing the order for flupenthixol with the pharmacy.

Flupenthixol is a generic medicine name and there are several brands available for it. Some of the brands for flupenthixol might be better known than flupenthixol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flupenthixol in stock, you can ask for one of the branded alternatives for flupenthixol.