Dopamine Pharmacology


About Dopamine
Adrenergic Agonist Agent, Phenethylamine derivative, Inotropic agents,Neurotransmitter,Vasopressor.
Mechanism of Action of Dopamine
The drug exerts it`s pharmacological action by acting as a dopaminergic (both D1&D2) receptor and adrenergic (alpha 1 & ?1) receptor agonist. It dilates renal and mesenteric blood vessels through its D1 receptor action by increasing intracellular cyclic AMP. It increases glomerular filtration rate and Na+ excretion. It is a positive inotropic drug and increases cardiac out put and systolic BP. It also causes coronary vasodilatation. High doses causes increased peripheral resistance and renal vasoconstriction

Pharmacokinets of Dopamine
It administered intravenously.
Distribution: Widely distributed throughout the body but does not crosses blood brain barrier.
Metabolism: Metabolized in to inactive metabolites in liver, kidney, plasma. About 25% is metabolized in to nor- epinephrine.
Excretion: Excreted mainly through urine as metabolites.
Onset of Action for Dopamine
Within 5 minutes
Duration of Action for Dopamine
<10 minutes
Half Life of Dopamine
Side Effects of Dopamine
1. Hypertension
2. Hypotension
3. Bradycardia
4. Ectopic beats
5. Tachycardia
6. Palpitations
7. Chest pain
8. Episodes of asthma
9. Hypersensitivity reactions
10. Nausea
11. Vomiting
12. Headache
13. Widening of QRS complex

Contra-indications of Dopamine
1. Hypersensitivity to the drug
2. Ventricular or Atrial tachyarrhythmia
3. Phaeochromocytoma
4. Hyperthyroidism
5. Ventricular fibrillation

Special Precautions while taking Dopamine
1. Occlusive vascular diseases
2. Cold injuries
3. Diabetic endarteritis
4. Along with MAO inhibitors
5. Gradually withdraw the drug with caution
6. Hypovolemia should be corrected before therapy using suitable volume expanders
7. Do not mix the drug with sodium bicarbonate or other drugs

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Dopamine
1. Acute myocardial infarction
2. Cardiogenic Shock
3. Septic Shock
4. Shock due to trauma
5. During cardiac surgery
6. Short term management of chronic heart failure
7. Shock due to renal failure

Interactions for Dopamine
Typical Dosage for Dopamine
In shock to increase cardiac out put, blood pressure, and urine volume:
2 to 50mcg/kg/minute as I.V. infusion. Dosage adjustment is based on patient`s response. Rate may be increased by 1 to 4mcg/kg/minute at 10 to 30minute intervals until optimum response is achieved.
Short term management of heart failure:
Starts with 0.5 to 2mcg/kg/minute as I.V. infusion. Dosage may be increase up to 3mcg/kg/minute based on patient`s response.
Children: 2 to 20 mcg/kg/minute based on patient`s response.
Schedule of Dopamine
Storage Requirements for Dopamine
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Dopamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dopamine
Treatment includes dosage reduction or withdrawal of the drug. If that fails to lower blood pressure use a short acting alpha blocking agent.

Home Delivery for Dopamine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dopamine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dopamine and other medicines and health products. Home delivery services for dopamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dopamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dopamine before they complete the sale. You can get this information while placing the order for dopamine with the pharmacy.

Dopamine is a generic medicine name and there are several brands available for it. Some of the brands for dopamine might be better known than dopamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dopamine in stock, you can ask for one of the branded alternatives for dopamine.