Rivastigmine Pharmacology


About Rivastigmine
A central reversible non competitive Anticholinesterase, Antidementia.
Mechanism of Action of Rivastigmine
Alzheimer`s disease may result from a deficiency in neurotransmitters used by nerves in the brain to communicate with one another. Rivastigmine exerts its therapeutic effect by enhancing its cholinergic function. It increases the concentration of Acetylcholine through reversible inhibition of acetyl cholinesterase enzyme which is involved in the hydrolysis of Acetylcholine. It leads to increased concentration of Acetylcholine.This increased Acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with Rivastigmine.
Pharmacokinets of Rivastigmine
Absorption: It is rapidly absorbed after oral administration and its bioavailability is about 40%. Distribution: Rivastigmine is widely distributed in the body in protein bound and unbound form. It crosses blood brain barrier
Metabolism: It is extensively metabolised in the liver. Excretion: Rivastigmine and its metabolites are excreted mainly in urine and very small amount in faeces.
Onset of Action for Rivastigmine
Duration of Action for Rivastigmine
10 hours
Half Life of Rivastigmine
1.5 hours
Side Effects of Rivastigmine
1. Nausea
2. Vomiting
3. Diarrhoea
4. Anorexia
5. Headache
6. Fatigue
7. Dizziness
8. Accidental trauma
9. Insomnia
10. Syncope
11. Agitation
12. Confusion
13. Gastrointestinal haemorrhage
14. Frequent urination
15. Increased sweating
16. Asthenia
17. Urinary tract infection
Contra-indications of Rivastigmine
1. Hypersensitivity to Rivastigmine
Special Precautions while taking Rivastigmine
1. Hepatic impairment
2. Renal impairment
3. Cardiovascular diseases
4. Supraventricular cardiac conduction conditions like sick sinus syndrome
5. Asthma
6. Chronic obstructive pulmonary diseases
7. Ulcers (gastric or duodenal)
8. Use caution while driving vehicles, operating machine or performing any hazardous activities.

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Rivastigmine
1. Mild to moderate dementia of the Alzheimer`s type.
Interactions for Rivastigmine
Typical Dosage for Rivastigmine
Adult: 3mg / day in 2 divided doses with food dose can be increased by 3mg / day every 2 weeks.
Maximum dose: 12 mg / day
Schedule of Rivastigmine
Storage Requirements for Rivastigmine
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Rivastigmine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Rivastigmine
Give supportive measures and symptomatic treatment. Atropine can be given as antidote.

Home Delivery for Rivastigmine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rivastigmine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rivastigmine and other medicines and health products. Home delivery services for rivastigmine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take rivastigmine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rivastigmine before they complete the sale. You can get this information while placing the order for rivastigmine with the pharmacy.

Rivastigmine is a generic medicine name and there are several brands available for it. Some of the brands for rivastigmine might be better known than rivastigmine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rivastigmine in stock, you can ask for one of the branded alternatives for rivastigmine.