Sulbutiamine Pharmacology


About Sulbutiamine
A synthetic derivative of thiamine, a centrally acting cholinergic agent, Nootropic,antiasthenic.
Mechanism of Action of Sulbutiamine
Sulbutiamine is a centrally acting cholinergic agent. This drug inhibits the enzyme Acetyl cholinesterase and prolongs the action of Acetylcholine- a stimulating hormone in the brain. This increased Acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with donepezil.
Sulbutiamine is a thiamine derivative. Being lipophilic it crosses the blood brain barrier and leads to increased formation of thiamine triphosphate which regulates the synaptic transmission of many neurotransmission system.

Pharmacokinets of Sulbutiamine
Absorption: Sulbutiamine is rapidly absorbed after oral administration.
Distribution: It is very widely distributed in the body.
Excretion: It is excreted mainly in urine
Onset of Action for Sulbutiamine
Within 1 day
Duration of Action for Sulbutiamine
1 day
Half Life of Sulbutiamine
5 hours
Side Effects of Sulbutiamine
1. Mild agitation ( in the elderly)
2. Allergic skin rash
Contra-indications of Sulbutiamine
1. Hypersensitivity to Sulbutiamine
Special Precautions while taking Sulbutiamine
1. Liver diseases
2. Kidney disease
3. Heart failure
Pregnancy Related Information
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Sulbutiamine
1. Wakefulness
2. Improve long term memory
3. Speed up reaction time
4. Asthenia
Interactions for Sulbutiamine
Typical Dosage for Sulbutiamine
Adults: 400 mg / day to be taken with breakfast. Dose can be increased to 600 mg / day in 2 - 3 divided doses as necessary.
Schedule of Sulbutiamine
Storage Requirements for Sulbutiamine
Store at cool dry area in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Sulbutiamine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Do not double the dose
Effects of Overdose of Sulbutiamine
Give supportive measures and symptomatic treatment.

Home Delivery for Sulbutiamine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sulbutiamine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sulbutiamine and other medicines and health products. Home delivery services for sulbutiamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sulbutiamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sulbutiamine before they complete the sale. You can get this information while placing the order for sulbutiamine with the pharmacy.

Sulbutiamine is a generic medicine name and there are several brands available for it. Some of the brands for sulbutiamine might be better known than sulbutiamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sulbutiamine in stock, you can ask for one of the branded alternatives for sulbutiamine.