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- Pharmacology For Tacrine
TacrineAbout TacrineCentral reversible acetylcholinesterase Inhibitor , Antidementia.Mechanism of Action of TacrineAlzheimer`s disease may result from a deficiency in neurotransmitters used by nerves in the brain to communicate with one another. Tacrine exerts its therapeutic effect by enhancing its cholinergic function. It increases the concentration of Acetylcholine through reversible inhibition of acetyl cholinesterase enzyme which is involved in the hydrolysis of Acetylcholine. It leads to increased concentration of Acetylcholine. This increased Acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with Tacrine.Pharmacokinets of TacrineAbsorption: It is rapidly absorbed after oral administration. Bioavailability is only about 17% since it undergoes first pass metabolism.
Distribution: About 55% of the drug is distributed in protein bound form.
Metabolism: It undergoes metabolism in the liver
Onset of Action for TacrineN/ADuration of Action for TacrineN/AHalf Life of Tacrine2 - 4 hoursSide Effects of Tacrine1.Headache
Contra-indications of TacrineHypersensitivity to TacrineSpecial Precautions while taking Tacrine1.Hepatic impairment
3.Sick sinus syndrome
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Tacrine1.Dementia
Interactions for TacrineN/ATypical Dosage for TacrineAdult:40mg/day in 4 divided doses, if needed doses can be increased by 40mg every month upto 160mg/day.Schedule of TacrineN/AStorage Requirements for TacrineStore it at 15 -25 degree C in a tightly closed container.Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of TacrineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TacrineGive supportive measures and symptomatic treatment. Atropine can be given as antidote for Tacrine poisoning.
Home Delivery for Tacrine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tacrine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tacrine and other medicines and health products. Home delivery services for tacrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tacrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tacrine before they complete the sale. You can get this information while placing the order for tacrine with the pharmacy.
Tacrine is a generic medicine name and there are several brands available for it. Some of the brands for tacrine might be better known than tacrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tacrine in stock, you can ask for one of the branded alternatives for tacrine.