Meclizine Pharmacology


About Meclizine
First Generation H1 Antagonist, Piperazine derivative, Antihistamine, antiemetic, antinauseant.
Mechanism of Action of Meclizine
Meclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Meclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.
Meclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also

Pharmacokinets of Meclizine
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.
Onset of Action for Meclizine
1 hour
Duration of Action for Meclizine
8 - 24 hours
Half Life of Meclizine
6 hours
Side Effects of Meclizine
2.Dry mouth
4.Urine retention
5.Blurred vision
7.Abdominal discomfort
Contra-indications of Meclizine
1.Hypersensitivity to Meclizine
Special Precautions while taking Meclizine
3.Prostate hypertrophy
5.Patient should be cautioned about driving vehicle or operating machines

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
CHILDREN below12 years: contraindicated
NEONATES: contraindicated
Indications for Meclizine
2.Motion sickness
Interactions for Meclizine
Typical Dosage for Meclizine
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey
Children above 12 years:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey

Schedule of Meclizine
Storage Requirements for Meclizine
Store the drug at room temperature in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Meclizine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Meclizine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Hypotension can be treated with vasopressors and seizure with Diazepam or Phenytoin.

Home Delivery for Meclizine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including meclizine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for meclizine and other medicines and health products. Home delivery services for meclizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take meclizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for meclizine before they complete the sale. You can get this information while placing the order for meclizine with the pharmacy.

Meclizine is a generic medicine name and there are several brands available for it. Some of the brands for meclizine might be better known than meclizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have meclizine in stock, you can ask for one of the branded alternatives for meclizine.