Cyclizine Pharmacology

Cyclizine

About Cyclizine
Piperazine derivative , First Generation histamine H1- antagonist, Antihistamine,Antiemetic.
Mechanism of Action of Cyclizine
Cyclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Cyclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.
Cyclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also
Pharmacokinets of Cyclizine
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.
Onset of Action for Cyclizine
N/A
Duration of Action for Cyclizine
N/A
Half Life of Cyclizine
N/A
Side Effects of Cyclizine
1.Drowsiness
2.Blurred vision
3.Stomach upset
4.Headache
5.Dry mouth
Contra-indications of Cyclizine
1.Hypersensitivity to Cyclizine
Special Precautions while taking Cyclizine
1.Glaucoma
2.Prostate hypertrophy
3.Urinary problems
4.Asthma
5.Patient should be cautioned against driving vehicle, operating machine and activities
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
contraindicated
Children Related Information
Use with caution
CHILDREN below12 years: contraindicated
Indications for Cyclizine
1.Nausea
2.Vomiting
3.Vertigo
4.Motion sickness
5.Labyrinthine disorders
Interactions for Cyclizine
N/A
Typical Dosage for Cyclizine
Oral:
Adult: 50mg 3 times daily
Children 6 - 12 years: 25mg 3 times daily
Motion sickness:50mg to be taken 30 minutes before traveling.
Schedule of Cyclizine
G
Storage Requirements for Cyclizine
Store the drug at room temperature in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Cyclizine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cyclizine
Provide symptomatic treatment and supportive measures.

Home Delivery for Cyclizine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cyclizine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cyclizine and other medicines and health products. Home delivery services for cyclizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cyclizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cyclizine before they complete the sale. You can get this information while placing the order for cyclizine with the pharmacy.

Cyclizine is a generic medicine name and there are several brands available for it. Some of the brands for cyclizine might be better known than cyclizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cyclizine in stock, you can ask for one of the branded alternatives for cyclizine.