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- Pharmacology For Doxylamine Succinate + Folic acid
Doxylamine Succinate + Folic acid Pharmacology
Doxylamine Succinate + Folic acid
About Doxylamine Succinate + Folic acidN/AMechanism of Action of Doxylamine Succinate + Folic acidN/APharmacokinets of Doxylamine Succinate + Folic acidN/AOnset of Action for Doxylamine Succinate + Folic acidN/ADuration of Action for Doxylamine Succinate + Folic acidN/AHalf Life of Doxylamine Succinate + Folic acidN/ASide Effects of Doxylamine Succinate + Folic acidN/AContra-indications of Doxylamine Succinate + Folic acidN/ASpecial Precautions while taking Doxylamine Succinate + Folic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Doxylamine Succinate + Folic acidN/AInteractions for Doxylamine Succinate + Folic acidN/ATypical Dosage for Doxylamine Succinate + Folic acidN/ASchedule of Doxylamine Succinate + Folic acidN/AStorage Requirements for Doxylamine Succinate + Folic acidN/AEffects of Missed Dosage of Doxylamine Succinate + Folic acidN/AEffects of Overdose of Doxylamine Succinate + Folic acidN/ADoxylamine Succinate
About Doxylamine SuccinateFirst Generation H1 Antagonist, Ethanolamine Derivative, Antiemetic, Antihistamine.
Mechanism of Action of Doxylamine SuccinateDoxylamine succinate is an ethanolamine derivative. It blocks the effect of Histamine and also induces sedation. It has anticholinergic and Antiemetic properties also.Pharmacokinets of Doxylamine SuccinateAbsorption: Doxylamine succinate is absorbed after oral administration. Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted mainly in urineOnset of Action for Doxylamine SuccinateN/ADuration of Action for Doxylamine SuccinateN/AHalf Life of Doxylamine Succinate10 hoursSide Effects of Doxylamine Succinate1.Drowsiness
2.Dry mouth
3.Blurred vision
4.Dizziness
5.Urinary retention
6.Abdominal discomfort
Contra-indications of Doxylamine Succinate1.Asthma
2.Glaucoma
3.Prostatic hypertrophy
4.Hypersensitivity to Doxylamine succinate
Special Precautions while taking Doxylamine Succinate1.Narrow angle glaucoma
2.Pyloroduodenal obstruction
3.Epilepsy
4.Urinary retention
5.Cardiac failure
6.Hypertension
7.Avoid alcohol
8.Patient should be cautioned about driving vehicle or operating machines
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 12 year: contraindicatedIndications for Doxylamine Succinate1.Nausea and vomiting in pregnancy
2.Insomnia
Interactions for Doxylamine SuccinateAlcohol, MAOIs & CNS depressants: CNS depressant effect enhanced.
Atropine and TCAs: Additive anti-muscarinic effect.Typical Dosage for Doxylamine SuccinateAdult:
Insomnia: 25 mg to be taken half an hour before going to bed.
Schedule of Doxylamine SuccinateGStorage Requirements for Doxylamine SuccinateStore the drug at 15 - 30 degree C in tightly closed container. Protect from heat and light.Effects of Missed Dosage of Doxylamine SuccinateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Doxylamine SuccinateGive supportive measures and symptomatic treatment.Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Home Delivery for Doxylamine Succinate + Folic acid in Your City
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Doxylamine Succinate + Folic acid is a generic medicine name and there are several brands available for it. Some of the brands for doxylamine succinate + folic acid might be better known than doxylamine succinate + folic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxylamine succinate + folic acid in stock, you can ask for one of the branded alternatives for doxylamine succinate + folic acid.
