Doxylamine Succinate + Pyridoxine + Folic acid Pharmacology

Doxylamine Succinate + Pyridoxine + Folic acid

About Doxylamine Succinate + Pyridoxine + Folic acid
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Mechanism of Action of Doxylamine Succinate + Pyridoxine + Folic acid
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Pharmacokinets of Doxylamine Succinate + Pyridoxine + Folic acid
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Onset of Action for Doxylamine Succinate + Pyridoxine + Folic acid
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Duration of Action for Doxylamine Succinate + Pyridoxine + Folic acid
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Half Life of Doxylamine Succinate + Pyridoxine + Folic acid
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Side Effects of Doxylamine Succinate + Pyridoxine + Folic acid
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Contra-indications of Doxylamine Succinate + Pyridoxine + Folic acid
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Special Precautions while taking Doxylamine Succinate + Pyridoxine + Folic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Doxylamine Succinate + Pyridoxine + Folic acid
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Interactions for Doxylamine Succinate + Pyridoxine + Folic acid
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Typical Dosage for Doxylamine Succinate + Pyridoxine + Folic acid
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Schedule of Doxylamine Succinate + Pyridoxine + Folic acid
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Storage Requirements for Doxylamine Succinate + Pyridoxine + Folic acid
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Effects of Missed Dosage of Doxylamine Succinate + Pyridoxine + Folic acid
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Effects of Overdose of Doxylamine Succinate + Pyridoxine + Folic acid
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Doxylamine Succinate

About Doxylamine Succinate
First Generation H1 Antagonist, Ethanolamine Derivative, Antiemetic, Antihistamine.
Mechanism of Action of Doxylamine Succinate
Doxylamine succinate is an ethanolamine derivative. It blocks the effect of Histamine and also induces sedation. It has anticholinergic and Antiemetic properties also.
Pharmacokinets of Doxylamine Succinate
Absorption: Doxylamine succinate is absorbed after oral administration. Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted mainly in urine
Onset of Action for Doxylamine Succinate
N/A
Duration of Action for Doxylamine Succinate
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Half Life of Doxylamine Succinate
10 hours
Side Effects of Doxylamine Succinate
1.Drowsiness
2.Dry mouth
3.Blurred vision
4.Dizziness
5.Urinary retention
6.Abdominal discomfort
Contra-indications of Doxylamine Succinate
1.Asthma
2.Glaucoma
3.Prostatic hypertrophy
4.Hypersensitivity to Doxylamine succinate
Special Precautions while taking Doxylamine Succinate
1.Narrow angle glaucoma
2.Pyloroduodenal obstruction
3.Epilepsy
4.Urinary retention
5.Cardiac failure
6.Hypertension
7.Avoid alcohol
8.Patient should be cautioned about driving vehicle or operating machines
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
CHILDREN below 12 year: contraindicated
Indications for Doxylamine Succinate
1.Nausea and vomiting in pregnancy
2.Insomnia
Interactions for Doxylamine Succinate
Alcohol, MAOIs & CNS depressants: CNS depressant effect enhanced.
Atropine and TCAs: Additive anti-muscarinic effect.
Typical Dosage for Doxylamine Succinate
Adult:
Insomnia: 25 mg to be taken half an hour before going to bed.
Schedule of Doxylamine Succinate
G
Storage Requirements for Doxylamine Succinate
Store the drug at 15 - 30 degree C in tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Doxylamine Succinate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Doxylamine Succinate
Give supportive measures and symptomatic treatment.

Pyridoxine

About Pyridoxine
Water soluble vitamin(Vit B6), In Vitamin B6 deficiency ,Neuropathy.
Mechanism of Action of Pyridoxine
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Pharmacokinets of Pyridoxine
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Onset of Action for Pyridoxine
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Duration of Action for Pyridoxine
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Half Life of Pyridoxine
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Side Effects of Pyridoxine
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Contra-indications of Pyridoxine
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Special Precautions while taking Pyridoxine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Pyridoxine
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Interactions for Pyridoxine
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Typical Dosage for Pyridoxine
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Schedule of Pyridoxine
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Storage Requirements for Pyridoxine
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Effects of Missed Dosage of Pyridoxine
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Effects of Overdose of Pyridoxine
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Folic Acid

About Folic Acid
Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.
Mechanism of Action of Folic Acid
Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinets of Folic Acid
Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic Acid
Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic Acid
Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic Acid
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Side Effects of Folic Acid
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Contra-indications of Folic Acid
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Special Precautions while taking Folic Acid
1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid
1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid
1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic Acid
Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic Acid
C1 (Oral)
C (Parenteral)
Storage Requirements for Folic Acid
Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.
Effects of Missed Dosage of Folic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Folic Acid
Relatively non toxic. Provide symptomatic treatment and supportive measures.

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