Meclizine + Nicotinic acid Pharmacology

Meclizine + Nicotinic acid

About Meclizine + Nicotinic acid
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Mechanism of Action of Meclizine + Nicotinic acid
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Pharmacokinets of Meclizine + Nicotinic acid
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Onset of Action for Meclizine + Nicotinic acid
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Duration of Action for Meclizine + Nicotinic acid
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Half Life of Meclizine + Nicotinic acid
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Side Effects of Meclizine + Nicotinic acid
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Contra-indications of Meclizine + Nicotinic acid
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Special Precautions while taking Meclizine + Nicotinic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Meclizine + Nicotinic acid
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Interactions for Meclizine + Nicotinic acid
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Typical Dosage for Meclizine + Nicotinic acid
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Schedule of Meclizine + Nicotinic acid
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Storage Requirements for Meclizine + Nicotinic acid
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Effects of Missed Dosage of Meclizine + Nicotinic acid
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Effects of Overdose of Meclizine + Nicotinic acid
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Meclizine

About Meclizine
First Generation H1 Antagonist, Piperazine derivative, Antihistamine, antiemetic, antinauseant.
Mechanism of Action of Meclizine
Meclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Meclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.
Meclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also

Pharmacokinets of Meclizine
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.
Onset of Action for Meclizine
1 hour
Duration of Action for Meclizine
8 - 24 hours
Half Life of Meclizine
6 hours
Side Effects of Meclizine
1.Drowsiness
2.Dry mouth
3.Restlessness
4.Urine retention
5.Blurred vision
6.Constipation
7.Abdominal discomfort
Contra-indications of Meclizine
1.Hypersensitivity to Meclizine
Special Precautions while taking Meclizine
1.Glaucoma
2.Asthma
3.Prostate hypertrophy
4.Alcoholics
5.Patient should be cautioned about driving vehicle or operating machines

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
CHILDREN below12 years: contraindicated
NEONATES: contraindicated
Indications for Meclizine
1.Dizziness
2.Motion sickness
3.Vertigo
Interactions for Meclizine
N/A
Typical Dosage for Meclizine
Adult:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey
Children above 12 years:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey

Schedule of Meclizine
G
Storage Requirements for Meclizine
Store the drug at room temperature in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Meclizine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Meclizine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Hypotension can be treated with vasopressors and seizure with Diazepam or Phenytoin.

Nicotinic Acid

About Nicotinic Acid
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Mechanism of Action of Nicotinic Acid
Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Nicotinic Acid
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Nicotinic Acid
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Duration of Action for Nicotinic Acid
N/A
Half Life of Nicotinic Acid
N/A
Side Effects of Nicotinic Acid
1. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Nicotinic Acid
1. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Nicotinic Acid
1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of Statins
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Nicotinic Acid
1. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)
Interactions for Nicotinic Acid
N/A
Typical Dosage for Nicotinic Acid
Oral:
Peripheral vascular diseases: 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia: 1.5 to 6g daily in two to four divided doses with or after meals.

Schedule of Nicotinic Acid
C1
Storage Requirements for Nicotinic Acid
Store at controlled room temperature at a range of 15 to 30 degree C
Effects of Missed Dosage of Nicotinic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nicotinic Acid
Provide supportive measures and symptomatic treatment

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Meclizine + Nicotinic acid is a generic medicine name and there are several brands available for it. Some of the brands for meclizine + nicotinic acid might be better known than meclizine + nicotinic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have meclizine + nicotinic acid in stock, you can ask for one of the branded alternatives for meclizine + nicotinic acid.