Meclizine + Vit B6 Pharmacology

Meclizine + Vit B6

About Meclizine + Vit B6
N/A
Mechanism of Action of Meclizine + Vit B6
N/A
Pharmacokinets of Meclizine + Vit B6
N/A
Onset of Action for Meclizine + Vit B6
N/A
Duration of Action for Meclizine + Vit B6
N/A
Half Life of Meclizine + Vit B6
N/A
Side Effects of Meclizine + Vit B6
N/A
Contra-indications of Meclizine + Vit B6
N/A
Special Precautions while taking Meclizine + Vit B6
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Meclizine + Vit B6
N/A
Interactions for Meclizine + Vit B6
N/A
Typical Dosage for Meclizine + Vit B6
N/A
Schedule of Meclizine + Vit B6
N/A
Storage Requirements for Meclizine + Vit B6
N/A
Effects of Missed Dosage of Meclizine + Vit B6
N/A
Effects of Overdose of Meclizine + Vit B6
N/A

Meclizine

About Meclizine
First Generation H1 Antagonist, Piperazine derivative, Antihistamine, antiemetic, antinauseant.
Mechanism of Action of Meclizine
Meclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Meclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.
Meclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also

Pharmacokinets of Meclizine
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.
Onset of Action for Meclizine
1 hour
Duration of Action for Meclizine
8 - 24 hours
Half Life of Meclizine
6 hours
Side Effects of Meclizine
1.Drowsiness
2.Dry mouth
3.Restlessness
4.Urine retention
5.Blurred vision
6.Constipation
7.Abdominal discomfort
Contra-indications of Meclizine
1.Hypersensitivity to Meclizine
Special Precautions while taking Meclizine
1.Glaucoma
2.Asthma
3.Prostate hypertrophy
4.Alcoholics
5.Patient should be cautioned about driving vehicle or operating machines

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
CHILDREN below12 years: contraindicated
NEONATES: contraindicated
Indications for Meclizine
1.Dizziness
2.Motion sickness
3.Vertigo
Interactions for Meclizine
N/A
Typical Dosage for Meclizine
Adult:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey
Children above 12 years:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey

Schedule of Meclizine
G
Storage Requirements for Meclizine
Store the drug at room temperature in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Meclizine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Meclizine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Hypotension can be treated with vasopressors and seizure with Diazepam or Phenytoin.

Vit B6

About Vit B6
Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.
Mechanism of Action of Vit B6
Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.
Pharmacokinets of Vit B6
Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6
N/A
Duration of Action for Vit B6
N/A
Half Life of Vit B6
15-20 days
Side Effects of Vit B6
1. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B6
1. Hypersensitivity to Vitamin B6
Special Precautions while taking Vit B6
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Vit B6
1. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6
Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6
Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6
N/A
Storage Requirements for Vit B6
Store it at 15 - 30 degree C. Protect from moisture and heat.
Effects of Missed Dosage of Vit B6
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B6
Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.

Home Delivery for Meclizine + Vit B6 in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including meclizine + vit b6.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for meclizine + vit b6 and other medicines and health products. Home delivery services for meclizine + vit b6 may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take meclizine + vit b6 only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for meclizine + vit b6 before they complete the sale. You can get this information while placing the order for meclizine + vit b6 with the pharmacy.

Meclizine + Vit B6 is a generic medicine name and there are several brands available for it. Some of the brands for meclizine + vit b6 might be better known than meclizine + vit b6 itself. If the pharmacy that's willing to deliver medicines to your home doesn't have meclizine + vit b6 in stock, you can ask for one of the branded alternatives for meclizine + vit b6.