Granisetron Pharmacology


About Granisetron
Selective 5HT3 receptor antagonist, Tropane derivative, Antiemetic, antinauseant.
Mechanism of Action of Granisetron
Granisetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain.
Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Granisetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy.
Pharmacokinets of Granisetron
Absorption: not known. Distribution: It is distributed in protein bound form. Metabolism: Granisetron is extensively metabolised in the liver. Excretion: It is excreted in the urine and also in the faeces
Onset of Action for Granisetron
1 - 3 minutes
Duration of Action for Granisetron
12 hours.
Half Life of Granisetron
4 - 6 hours
Side Effects of Granisetron
7.Allergic reactions
11.Elevated liver enzymes
Contra-indications of Granisetron
1.Hypersensitivity to Granisetron
Special Precautions while taking Granisetron
1. Hepatic impairment
2. Intestinal obstruction
Pregnancy Related Information
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
CHILDREN below 2 year: contraindicated
Indications for Granisetron
1.Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy.
Interactions for Granisetron
Inducers or inhibitors of hepatic cytochrome P450 drug metabolising enzymes: Granisetron does not induce or inhibit the cytochrome P450 drug metabolising enzyme system.
Typical Dosage for Granisetron
Adult: ORAL
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:
1mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after 12 hours.
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:
Adult: 10mcg / kg IV infusion over 5 minutes should be given half an hour before starting chemotherapy.
CHILDREN 2 - 16 years
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:
10mcg / kg IV infusion over 5 minutes should be given half an hour before starting chemotherapy
ORALDOSE: not recommended

Schedule of Granisetron
Storage Requirements for Granisetron
Store at room temperature. Protect from heat and light.
Effects of Missed Dosage of Granisetron
If you missed a dose and do not feel nauseated then skip the missed dose and go back regular schedule.
If you missed a dose and feel nauseated then take the missed dose as soon as possible.
Effects of Overdose of Granisetron
Give supportive measures and symptomatic treatment

Home Delivery for Granisetron in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including granisetron.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for granisetron and other medicines and health products. Home delivery services for granisetron may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take granisetron only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for granisetron before they complete the sale. You can get this information while placing the order for granisetron with the pharmacy.

Granisetron is a generic medicine name and there are several brands available for it. Some of the brands for granisetron might be better known than granisetron itself. If the pharmacy that's willing to deliver medicines to your home doesn't have granisetron in stock, you can ask for one of the branded alternatives for granisetron.