Ondansetron + Paracetamol Pharmacology

Ondansetron + Paracetamol

About Ondansetron + Paracetamol
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Mechanism of Action of Ondansetron + Paracetamol
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Pharmacokinets of Ondansetron + Paracetamol
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Onset of Action for Ondansetron + Paracetamol
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Duration of Action for Ondansetron + Paracetamol
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Half Life of Ondansetron + Paracetamol
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Side Effects of Ondansetron + Paracetamol
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Contra-indications of Ondansetron + Paracetamol
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Special Precautions while taking Ondansetron + Paracetamol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Ondansetron + Paracetamol
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Interactions for Ondansetron + Paracetamol
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Typical Dosage for Ondansetron + Paracetamol
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Schedule of Ondansetron + Paracetamol
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Storage Requirements for Ondansetron + Paracetamol
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Effects of Missed Dosage of Ondansetron + Paracetamol
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Effects of Overdose of Ondansetron + Paracetamol
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Ondansetron

About Ondansetron
Selective serotonin 5-HT3 receptor antagonist, Imidazole derivative, Antiemetic.
Mechanism of Action of Ondansetron
Ondansetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain.
Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.

Pharmacokinets of Ondansetron
Absorption: Ondansetron is well absorbed after oral administration and the bioavailability is 50 - 60 %.
Distribution: It is distributed in protein bound form.
Metabolism: Ondansetron is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine.
Onset of Action for Ondansetron
With in 30 minutes
Duration of Action for Ondansetron
8 - 10 hours
Half Life of Ondansetron
4 - 6 hours
Side Effects of Ondansetron
1. Headache
2. Dizziness
3. Constipation
4. Musculoskeletal pain
5. Chills
6. Allergic reactions
7. Agitation
8. Chest pain
9. Malaise
10. Urinary retention
11. Elevation in hepatic enzymes
12. Hypotension

Contra-indications of Ondansetron
1. Hypersensitivity to Ondansetron
Special Precautions while taking Ondansetron
1. Hepatic impairment
2. Intestinal obstruction
Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 6 months : Contraindicated
Indications for Ondansetron
1. Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy.
2. Post operative nausea and vomiting
Interactions for Ondansetron
Inducers of hepatic cytochrome P450 drug metabolising enzymes: May change the clearance and hence the half-life of ondansetron, but on the basis of available data there is no need to adjust the dose of ondansetron.
Typical Dosage for Ondansetron
Adult:
Oral :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:8 mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after the procedure every 12 hours for 1 - 2 days.
Post operative nausea and vomiting: 16 mg should be given 1 hour before anesthesia or soon after operation
IV Injection :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy: 0.15 mg / kg IV infusion over 15 minutes should be given half an hour before starting treatment and repeat the same dose 4th and 8th hour after first dose or a single dose of 32 mg IV infusion over 15 minutes should be given half an hour before starting the treatment.
Post operative nausea and vomiting: 4 mg IV should be given immediately before anesthesia or soon after operation
Children :
Oral :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:8 mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after the procedure every 12 hours for 1 - 2 days
Injection:
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:0.15 mg / kg IV infusion over 15 minutes should be given half an hour before starting treatment and repeat the same dose 4th and 8th hour after first dose
Children below 2 years: 0.1 mg / kg body weight as IV infusion
Maximum dose: 4 mg



Schedule of Ondansetron
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Storage Requirements for Ondansetron
Store at room temperature. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Ondansetron
If you missed a dose and do not feel nauseated then skip the missed dose and go back regular schedule.
If you missed a dose and feel nauseated then take the missed dose as soon as possible.
Effects of Overdose of Ondansetron
Give supportive measures and symptomatic treatment.

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Home Delivery for Ondansetron + Paracetamol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ondansetron + paracetamol and other medicines and health products. Home delivery services for ondansetron + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

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Ondansetron + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for ondansetron + paracetamol might be better known than ondansetron + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ondansetron + paracetamol in stock, you can ask for one of the branded alternatives for ondansetron + paracetamol.