Ondansetron + Paracetamol Pharmacology
Ondansetron + Paracetamol
Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Distribution: It is distributed in protein bound form.
Metabolism: Ondansetron is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine.
4. Musculoskeletal pain
6. Allergic reactions
8. Chest pain
10. Urinary retention
11. Elevation in hepatic enzymes
2. Intestinal obstruction
Below 6 months : Contraindicated
2. Post operative nausea and vomiting
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:8 mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after the procedure every 12 hours for 1 - 2 days.
Post operative nausea and vomiting: 16 mg should be given 1 hour before anesthesia or soon after operation
IV Injection :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy: 0.15 mg / kg IV infusion over 15 minutes should be given half an hour before starting treatment and repeat the same dose 4th and 8th hour after first dose or a single dose of 32 mg IV infusion over 15 minutes should be given half an hour before starting the treatment.
Post operative nausea and vomiting: 4 mg IV should be given immediately before anesthesia or soon after operation
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:8 mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after the procedure every 12 hours for 1 - 2 days
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:0.15 mg / kg IV infusion over 15 minutes should be given half an hour before starting treatment and repeat the same dose 4th and 8th hour after first dose
Children below 2 years: 0.1 mg / kg body weight as IV infusion
Maximum dose: 4 mg
If you missed a dose and feel nauseated then take the missed dose as soon as possible.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
2. Abdominal distress
3. Allergic reactions
2. Renal impairment
NEONATES : Contraindicated
2. Acute gout
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Ondansetron + Paracetamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ondansetron + paracetamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ondansetron + paracetamol and other medicines and health products. Home delivery services for ondansetron + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ondansetron + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ondansetron + paracetamol before they complete the sale. You can get this information while placing the order for ondansetron + paracetamol with the pharmacy.
Ondansetron + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for ondansetron + paracetamol might be better known than ondansetron + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ondansetron + paracetamol in stock, you can ask for one of the branded alternatives for ondansetron + paracetamol.