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- Pharmacology For Clobazam
ClobazamAbout ClobazamBenzodiazepine derivative, Anticonvulsant, anxiolyticMechanism of Action of ClobazamClobazam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and decreases firing rate of neuron. This in turn alters normal functions of the body and Clobazam is useful in epilepsy.Pharmacokinets of ClobazamAbsorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised to active metabolite (Desmethyl Clobazam) in the liver. Excretion: Most metabolites are excreted in urine.Onset of Action for Clobazam1 - 4 hourDuration of Action for ClobazamN/AHalf Life of Clobazam18 hourSide Effects of Clobazam1.Ataxia
Contra-indications of Clobazam1.Hypersensitivity to Clobazam
2.Acute narrow angle glaucomaSpecial Precautions while taking Clobazam1.Renal impairment
4.AlcoholicsPregnancy Related InformationUse with caution.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Clobazam1.Anticonvulsant in Complex partial
2.Secondarily generalised tonic-clonic
4.Atonic and Absence seizuresInteractions for ClobazamSome idiosyncratic drug interactions are observed with increased serum levels of phenytoin, phenobarbitone, carbamazepine and valproate.
Decreased serum levels of clobazam have also been observed when used with above mentioned drugs.Typical Dosage for ClobazamAdults : 20 - 60mg orally as a single bed time dose or two divided dose.
Elderly (for debilitated) 10-20mg daily.
Over 3 years : Half the adult dose.Schedule of ClobazamHStorage Requirements for ClobazamThe drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of ClobazamTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of ClobazamGive support and symptomatic treatment. Gastric lavage has to be done if the ingestion of the drug is recent. Urinary excretion of the drug can be increased by the administration of Loop diuretics Hypotension can be treated with vasopressors.If the patient is conscious induce emesis followed by charcoal administration
Home Delivery for Clobazam in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clobazam.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clobazam and other medicines and health products. Home delivery services for clobazam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take clobazam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clobazam before they complete the sale. You can get this information while placing the order for clobazam with the pharmacy.
Clobazam is a generic medicine name and there are several brands available for it. Some of the brands for clobazam might be better known than clobazam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clobazam in stock, you can ask for one of the branded alternatives for clobazam.