Ethosuximide Pharmacology

Ethosuximide

About Ethosuximide
Imide derivative, A succinimide anticonvulsant(mainly in absence seizures).
Mechanism of Action of Ethosuximide
Ethosuximide reduces low threshold T current in Ca2+ channel in thalamic neurons. Thalamus is responsible for the production of absence seizure. Ethosuximide produces its action by inhibiting T type calcium channel.
Pharmacokinets of Ethosuximide
Absorption: Drug is absorbed after oral administration. Distribution: It is widely distributed in the body in unbound form. Metabolism: It undergoes metabolism in the liver. Excretion: Drug and its metabolites are excreted in the urine.
Onset of Action for Ethosuximide
N/A
Duration of Action for Ethosuximide
N/A
Half Life of Ethosuximide
N/A
Side Effects of Ethosuximide
1.Anorexia
2.Gastric upset
3.Nausea
4.Vomiting
5.Abdominal pain
6.Weight loss
7.Diarrhoea
8.Leukopenia
9.Agranulocytosis
10.Eosinophilia
11.Drowsiness
12.Headache
13.Dizziness
14.Euphoria
15.Hiccups
16.Irritability
17.Lethargy
18.Fatigue
19.Ataxia
20.Urticaria
21.Rash
22.Urinary frequency
Contra-indications of Ethosuximide
Hypersensitivity to Ethosuximide
Special Precautions while taking Ethosuximide
1.Liver impairment
2.Renal impairment
3.Blood dyscrasias
4.Driving vehicles, operating machines and people involving any other dangerous activities
5.Slowly withdraw the drug with caution
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Below 3years: Contraindicated
Indications for Ethosuximide
Absence seizure (Petit mal epilepsy)
Interactions for Ethosuximide
N/A
Typical Dosage for Ethosuximide
Adult:
500mg/day in 2 divided doses. Dose can be increased by 250mg every 4 - 7 days up to 1.5g/day.
Children above 6 years of age: same as adult dose
Children under 6 years of age: 250 mg /day

Schedule of Ethosuximide
G
Storage Requirements for Ethosuximide
Store at room temperature between 15 and 30 degrees C. Keep away from moisture and sunlight.
Effects of Missed Dosage of Ethosuximide
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule. Do not double the dose.
Effects of Overdose of Ethosuximide
Give supportive measures and symptomatic treatment.

Home Delivery for Ethosuximide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ethosuximide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ethosuximide and other medicines and health products. Home delivery services for ethosuximide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ethosuximide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ethosuximide before they complete the sale. You can get this information while placing the order for ethosuximide with the pharmacy.

Ethosuximide is a generic medicine name and there are several brands available for it. Some of the brands for ethosuximide might be better known than ethosuximide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ethosuximide in stock, you can ask for one of the branded alternatives for ethosuximide.