Orphenadrine Pharmacology

Orphenadrine

About Orphenadrine
Anticholinergic(AntiMuscarinic),ethanolamine H1 antagonist, Anti-Parkinson`s Agent,Centrally acting skeletal muscle relaxent.
Mechanism of Action of Orphenadrine
The exact mechanism of action is not known. A lesion in the Nigra striatum may be responsible for Parkinson`s disease which results in a reduction in Dopamine concentrations. This in turn causes a relative imbalance between dopaminergic and cholinergic neurological pathways. Procyclidine acts by blocking the central muscarinic receptors (M1, M2 and M4 receptors). Thereby it balances cholinergic and dopaminergic action in the basal ganglia.
Skeletal muscle relaxant action: It reduces skeletal muscle spasm by its anticholinergic action on cerebral motor centers.
Orphenadrine binds to both H1 receptor and NMDA receptors. It restores the motor disturbances induced by Neuroleptics
Pharmacokinets of Orphenadrine
Absorption: Orphenadrine is absorbed rapidly.
Distribution: It is very widely distributed in the body.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted primarily in urine.
Onset of Action for Orphenadrine
60 minutes
Duration of Action for Orphenadrine
4 - 6 hours
Half Life of Orphenadrine
14 hours
Side Effects of Orphenadrine
1. Dry mouth
2. Nausea
3. Vomiting
4. Constipation
5. Abdominal cramps
6. Dizziness
7. Headache
8. Nervousness
9. Drowsiness
10. Blurred vision
11. Irritability
12. Tachycardia
13. Urinary retention
14. Mydriasis
15. Increased intraocular pressure
Contra-indications of Orphenadrine
1. Hypersensitivity to Ophenadrine
2. Narrow angle glaucoma
3. Prostatic hyperplasia
4. Gastrointestinal obstruction
5. Myasthenia gravis

Special Precautions while taking Orphenadrine
1. Renal impairment
2. Hepatic impairment
3. Tachycardia
4. Arrhythmia
5. Urinary retention
6. Peptic ulcer
7. Use with caution when driving vehicle or operating machines
8. Avoid alcohol
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Orphenadrine
1. Parkinsonism
2. Drug induced Extrapyramidal symptoms
3. Skeletal muscle Spasms
Interactions for Orphenadrine
Anticholinergics, MAOIs and Anti-depressants: Effects of these agents potentiated.
Propoxyphene: Confusion, anxiety and tremors.
Chlorpromazine: Therapeutic effects of chlorpromazine may be decreased.
Haloperidol: Worsening of schizophrenic symptoms, decreased haloperidol levels and development of tardive dyskinesias.
Levodopa: Synergistic effect.
Barbiturates, steroids and phenylbutazone: Orphenadrine antagonises effects of these drugs.
Typical Dosage for Orphenadrine
Adult:
Parkinsonism, Drug induced Extrapyramidal symptoms: 150 mg / day in 3 divided doses gradually increase the dose by 50 mg every 2 - 3 days until effective response is obtained.
Maintenance dose: 150 - 300 mg / day
Maximum dose: 400 mg / day
Pain and discomfort associated with musculoskeletal injuries and other conditions: 200 mg / day in 2 divided doses.
Schedule of Orphenadrine
H
Storage Requirements for Orphenadrine
Store at cool dry place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Orphenadrine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Orphenadrine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis or by gastric lavage. The absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Orphenadrine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including orphenadrine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for orphenadrine and other medicines and health products. Home delivery services for orphenadrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take orphenadrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for orphenadrine before they complete the sale. You can get this information while placing the order for orphenadrine with the pharmacy.

Orphenadrine is a generic medicine name and there are several brands available for it. Some of the brands for orphenadrine might be better known than orphenadrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have orphenadrine in stock, you can ask for one of the branded alternatives for orphenadrine.