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- Generic Medicines
- Pharmacology For Tetrabenazine
TetrabenazineAbout TetrabenazineA selective, reversible centrally-acting dopamine-depleting agent, a VMAT-inhibitor, In hyperkinetic movement disorders.Mechanism of Action of TetrabenazineTetrabenazine interferes with vesicular storage of neurotransmitters including Dopamine, Noradrenaline and Serotonin. These neurotransmitters are normally involved with the passage of messages between nerve cells in the brain and the normal functioning of the brain and nervous system. Tetrabenazine inhibits presynaptic Dopamine release and also antagonizes post synaptic Dopamine receptors. Depleting these neurotransmitters can help to control movement disorders caused by diseases of the brain and nervous system.. Tetrabenazine is mainly used to control movement disorders associated with diseases of the brain and nervous system.Pharmacokinets of TetrabenazineAbsorption: Tetrabenazine is absorbed after oral administration.
Distribution: It is distributed mainly in the body in unbound form.
Metabolism: Tetrabenazine is extensively undergoes first pass metabolism. It undergoes metabolism in the liver to active metabolite.
Excretion: It is excreted mainly in urine and small amount in faeces.
Onset of Action for TetrabenazineN/ADuration of Action for Tetrabenazine16 - 24 hoursHalf Life of Tetrabenazine10 hoursSide Effects of Tetrabenazine1. Drowsiness
6. Abdominal discomfort
Contra-indications of Tetrabenazine1. Hypersensitivity to Tetrabenazine
3. Patient on monoamine oxidase inhibitors
Special Precautions while taking Tetrabenazine1. Hepatic impairment
2. Renal impairment
3. Mental illness
5. Use caution when driving, operating machines and performing skilled tasks
6. Avoid alcohol
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
Indications for Tetrabenazine1. Treatment of hyperkinetic movement disorders (Huntington`s chorea, Hemiballismus, Senile chorea, Gilles de la Tourette`s syndrome and Tardive dyskinesia)Interactions for TetrabenazineN/ATypical Dosage for TetrabenazineAdult: 25 mg in 2 divided doses dose can be gradually increased by 12.5 mg /day every 3 - 5 days until sufficient therapeutic response is obtained.
Maximum dose: 200 mg / day
Schedule of TetrabenazineN/AStorage Requirements for TetrabenazineStore at 15 - 30 degree C in a well closed container. Keep out of the reach of children.Effects of Missed Dosage of TetrabenazineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TetrabenazineGive supportive measures and symptomatic treatment.
Home Delivery for Tetrabenazine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tetrabenazine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tetrabenazine and other medicines and health products. Home delivery services for tetrabenazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tetrabenazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tetrabenazine before they complete the sale. You can get this information while placing the order for tetrabenazine with the pharmacy.
Tetrabenazine is a generic medicine name and there are several brands available for it. Some of the brands for tetrabenazine might be better known than tetrabenazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tetrabenazine in stock, you can ask for one of the branded alternatives for tetrabenazine.