Tetrabenazine Pharmacology


About Tetrabenazine
A selective, reversible centrally-acting dopamine-depleting agent, a VMAT-inhibitor, In hyperkinetic movement disorders.
Mechanism of Action of Tetrabenazine
Tetrabenazine interferes with vesicular storage of neurotransmitters including Dopamine, Noradrenaline and Serotonin. These neurotransmitters are normally involved with the passage of messages between nerve cells in the brain and the normal functioning of the brain and nervous system. Tetrabenazine inhibits presynaptic Dopamine release and also antagonizes post synaptic Dopamine receptors. Depleting these neurotransmitters can help to control movement disorders caused by diseases of the brain and nervous system.. Tetrabenazine is mainly used to control movement disorders associated with diseases of the brain and nervous system.
Pharmacokinets of Tetrabenazine
Absorption: Tetrabenazine is absorbed after oral administration.
Distribution: It is distributed mainly in the body in unbound form.
Metabolism: Tetrabenazine is extensively undergoes first pass metabolism. It undergoes metabolism in the liver to active metabolite.
Excretion: It is excreted mainly in urine and small amount in faeces.
Onset of Action for Tetrabenazine
Duration of Action for Tetrabenazine
16 - 24 hours
Half Life of Tetrabenazine
10 hours
Side Effects of Tetrabenazine
1. Drowsiness
2. Weakness
3. Fatigue
4. Nausea
5. Vomiting
6. Abdominal discomfort
7. Agitation
8. Dizziness
9. Depression
10. Restlessness
11. Confusion
Contra-indications of Tetrabenazine
1. Hypersensitivity to Tetrabenazine
2. Depression
3. Patient on monoamine oxidase inhibitors

Special Precautions while taking Tetrabenazine
1. Hepatic impairment
2. Renal impairment
3. Mental illness
4. Parkinsonism
5. Use caution when driving, operating machines and performing skilled tasks
6. Avoid alcohol
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Tetrabenazine
1. Treatment of hyperkinetic movement disorders (Huntington`s chorea, Hemiballismus, Senile chorea, Gilles de la Tourette`s syndrome and Tardive dyskinesia)
Interactions for Tetrabenazine
Typical Dosage for Tetrabenazine
Adult: 25 mg in 2 divided doses dose can be gradually increased by 12.5 mg /day every 3 - 5 days until sufficient therapeutic response is obtained.
Maximum dose: 200 mg / day
Schedule of Tetrabenazine
Storage Requirements for Tetrabenazine
Store at 15 - 30 degree C in a well closed container. Keep out of the reach of children.
Effects of Missed Dosage of Tetrabenazine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tetrabenazine
Give supportive measures and symptomatic treatment.

Home Delivery for Tetrabenazine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tetrabenazine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tetrabenazine and other medicines and health products. Home delivery services for tetrabenazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tetrabenazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tetrabenazine before they complete the sale. You can get this information while placing the order for tetrabenazine with the pharmacy.

Tetrabenazine is a generic medicine name and there are several brands available for it. Some of the brands for tetrabenazine might be better known than tetrabenazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tetrabenazine in stock, you can ask for one of the branded alternatives for tetrabenazine.