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- Pharmacology For Cinnarizine + Domperidone
Cinnarizine + Domperidone Pharmacology
Cinnarizine + Domperidone
About Cinnarizine + DomperidoneN/AMechanism of Action of Cinnarizine + DomperidoneN/APharmacokinets of Cinnarizine + DomperidoneN/AOnset of Action for Cinnarizine + DomperidoneN/ADuration of Action for Cinnarizine + DomperidoneN/AHalf Life of Cinnarizine + DomperidoneN/ASide Effects of Cinnarizine + DomperidoneN/AContra-indications of Cinnarizine + DomperidoneN/ASpecial Precautions while taking Cinnarizine + DomperidoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Cinnarizine + DomperidoneN/AInteractions for Cinnarizine + DomperidoneN/ATypical Dosage for Cinnarizine + DomperidoneN/ASchedule of Cinnarizine + DomperidoneN/AStorage Requirements for Cinnarizine + DomperidoneN/AEffects of Missed Dosage of Cinnarizine + DomperidoneN/AEffects of Overdose of Cinnarizine + DomperidoneN/ACinnarizine
About CinnarizinePiperazines derivative, Antihistamine, Antivertigo.Mechanism of Action of CinnarizineCinnarizine is a specific competitive H1 receptor antagonist. It suppresses the vestibular end organ receptors and thus inhibits the activation of central cholinergic receptors. Cinnarizine inhibits contractions of vascular smooth muscles by inhibiting the calcium channels preferably in the arterial smooth muscle.Pharmacokinets of CinnarizineAbsorption: It is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Excretion: Excreted mainly in faeces and also in urineOnset of Action for CinnarizineWith in 30 minutesDuration of Action for CinnarizineUp to 8 hoursHalf Life of Cinnarizine3. 65 hoursSide Effects of Cinnarizine1.Headache
2.Diarrhoea
3.Constipation
4.Nausea
5.Vomiting
6.Abdominal pain
7.Weight gain
8.Drowsiness
9.Rash
10.Dry mouth.
Contra-indications of Cinnarizine1.Hypersensitivity to Cinnarizine
2.Parkinson`s diseas
Special Precautions while taking Cinnarizine1.Hypotension
2.Use caution while driving, operating machine or performing any hazardous activities
3.Avoid alcohol
Pregnancy Related InformationContraindicatedOld Age Related InformationContraindicatedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Cinnarizine1.Motion sickness
2.Vertigo and other vestibular disturbances
3.Vomiting in Meniere`s disease
4.Treatment of vascular disorders (peripheral & Cerebrovascular)
Interactions for CinnarizineAlcohol & CNS depressants: Action enhanced.
Domperidone: Enhances efficacy of cinnarizine.Typical Dosage for CinnarizineAdult:
Motion sickness: 30 mg to be taken 2 hour before beginning the journey and if necessary dose can be repeated every 8 hours
Vertigo and other vestibular disturbances, vomiting in Meniere`s disease: 90 mg / day in 3 divided doses
Treatment of vascular disorders (peripheral & cerebrovascular): 75 mg 1-3 times daily.
Children 5 - 12 years:
Motion sickness: 15 mg to be taken 2 hour before beginning the journey and if necessary dose can be repeated every 8 hours
Vertigo and other vestibular disturbances, vomiting in Meniere`s disease: 45mg / day in 3 divided doses.
Schedule of CinnarizineHStorage Requirements for CinnarizineStore below 25 degree C.Protect from light and moisture.Effects of Missed Dosage of CinnarizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CinnarizineGive supportive measures and symptomatic treatment.Domperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Home Delivery for Cinnarizine + Domperidone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cinnarizine + domperidone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cinnarizine + domperidone and other medicines and health products. Home delivery services for cinnarizine + domperidone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cinnarizine + domperidone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cinnarizine + domperidone before they complete the sale. You can get this information while placing the order for cinnarizine + domperidone with the pharmacy.
Cinnarizine + Domperidone is a generic medicine name and there are several brands available for it. Some of the brands for cinnarizine + domperidone might be better known than cinnarizine + domperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cinnarizine + domperidone in stock, you can ask for one of the branded alternatives for cinnarizine + domperidone.
