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- Pharmacology For Cetirizine + Pseudoephedrine
Cetirizine + Pseudoephedrine Pharmacology
Cetirizine + PseudoephedrineAbout Cetirizine + PseudoephedrineN/AMechanism of Action of Cetirizine + PseudoephedrineN/APharmacokinets of Cetirizine + PseudoephedrineN/AOnset of Action for Cetirizine + PseudoephedrineN/ADuration of Action for Cetirizine + PseudoephedrineN/AHalf Life of Cetirizine + PseudoephedrineN/ASide Effects of Cetirizine + PseudoephedrineN/AContra-indications of Cetirizine + PseudoephedrineN/ASpecial Precautions while taking Cetirizine + PseudoephedrineN/APregnancy Related InformationContraindicated; since Cetrizine is contraindicated in pregnancy; the combination generic is contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Cetrizine and Pseudoephedrine are contraindicated in breast feeding; the combination generic is contraindicated in breast feeding mother.Children Related InformationN/AIndications for Cetirizine + PseudoephedrineIt is a mixture of Cetrizine and Pseudoephidrine.
It is a combination of Non sedative antihistamine with Decongestant action, Cetrizine and decongestant Pseudoephedrine.
1. Nasal congestion
2. Allergic rhinitis
Interactions for Cetirizine + PseudoephedrineN/ATypical Dosage for Cetirizine + PseudoephedrineAdults and children 12 years of age and older: 1 tablet to be taken 2 times a day.Schedule of Cetirizine + PseudoephedrineN/AStorage Requirements for Cetirizine + PseudoephedrineN/AEffects of Missed Dosage of Cetirizine + PseudoephedrineN/AEffects of Overdose of Cetirizine + PseudoephedrineN/A
CetirizineAbout CetirizineSecond Generation H1 Antagonist, Metabolite of hydroxyzine, Antihistamine.Mechanism of Action of CetirizineThis drug is a selective peripheral H1 receptor antagonist. Thus it inhibits the allergic symptoms produced by histamines like cold, rhinorrhea, sneezing, urticaria etc. The drug has some mast cell stabilizing properties. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.Pharmacokinets of CetirizineAbsorption- Well absorbed after oral administration
Distribution-Widely distributed in the body. 93% bound to the plasma proteins. It enters to the CNS in small amounts.
Metabolism-Metabolized in the liver to its metabolites by oxidative O-dealkylation
Excretion- Excreted through urine (50% as unchanged form) and a small amount through feces
Onset of Action for Cetirizine10-30 minDuration of Action for Cetirizine12-24hrsHalf Life of CetirizineIts plasma half life is 8.3 hrsSide Effects of Cetirizine1. Somnolence.
5. Dry mouth
6. CNS stimulation in children
10. Blurred vision
16. Excessive tiredness
19. Sore throat
20. Stomach pain
Contra-indications of CetirizineHypersensitivity to the drug or hydroxyzine.Special Precautions while taking Cetirizine1. Renal impairment.
2. Hepatic dysfunction.
4. Any work which require mental alertness like driving or machine operation.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Cetirizine1. Sneezing
3. Postnasal discharge.
4. Common coughs
6. Chronic urticaria
8. Pruritic skin disorders
9. Hay fever
Interactions for CetirizineAlcohol: Avoid excessive alcohol consumption.Typical Dosage for CetirizineOral-
Adult - 10 mg daily, single dose
Children (6-12 years) -5 mg daily.
Schedule of CetirizineN/AStorage Requirements for CetirizineStore in cool, dry, dark placeEffects of Missed Dosage of CetirizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CetirizineGive symptomatic and supportive treatment.
PseudoephedrineAbout PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
4. CNS stimulation
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
5. Prostatic hyperplasia
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Cetirizine + Pseudoephedrine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cetirizine + pseudoephedrine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cetirizine + pseudoephedrine and other medicines and health products. Home delivery services for cetirizine + pseudoephedrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cetirizine + pseudoephedrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cetirizine + pseudoephedrine before they complete the sale. You can get this information while placing the order for cetirizine + pseudoephedrine with the pharmacy.
Cetirizine + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for cetirizine + pseudoephedrine might be better known than cetirizine + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cetirizine + pseudoephedrine in stock, you can ask for one of the branded alternatives for cetirizine + pseudoephedrine.