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- Pharmacology For Loratadine + Pseudoephedrine
Loratadine + Pseudoephedrine Pharmacology
Loratadine + Pseudoephedrine
About Loratadine + PseudoephedrineN/AMechanism of Action of Loratadine + PseudoephedrineN/APharmacokinets of Loratadine + PseudoephedrineN/AOnset of Action for Loratadine + PseudoephedrineN/ADuration of Action for Loratadine + PseudoephedrineN/AHalf Life of Loratadine + PseudoephedrineN/ASide Effects of Loratadine + PseudoephedrineN/AContra-indications of Loratadine + PseudoephedrineN/ASpecial Precautions while taking Loratadine + PseudoephedrineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Loratadine + PseudoephedrineN/AInteractions for Loratadine + PseudoephedrineN/ATypical Dosage for Loratadine + PseudoephedrineN/ASchedule of Loratadine + PseudoephedrineN/AStorage Requirements for Loratadine + PseudoephedrineN/AEffects of Missed Dosage of Loratadine + PseudoephedrineN/AEffects of Overdose of Loratadine + PseudoephedrineN/ALoratadine
About LoratadineSecond Generation H1 Antagonist, Antihistamine.Mechanism of Action of LoratadineLoratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation (activation releasing other chemicals which produce the symptoms associated with allergy) of cells by histamine. Drug also has mast cell stabilizing property.Pharmacokinets of LoratadineAbsorption- Rapidly absorbed after oral administration.
Distribution-Widely distributed in the body.97% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites, Descarboethoxyloratidine is its active metabolite.
Excretion- Excreted through both the urine and feces.
Onset of Action for Loratadine1 - 3 hrsDuration of Action for Loratadine24 hrsHalf Life of LoratadineN/ASide Effects of Loratadine1. Headache
2. Dry mouth, nose, and throat
3. Drowsiness
4. Rapid heartbeat
5. Difficulty urinating
6. Vision problems
7. Dizziness
8. Muscle weakness
9. Anxiety
10. Change in menstruation
11. Clumsiness
12. Depression
13. Feeling faint
14. Flushing of the face
15. Hallucinations
16. Migraines
17. Palpitations
18. Rash
19. Seizures
20. Shortness of breath
21. Sleeping disorders
22. Sore throat
23. Tightness in the chest or back
24. Yellowing of the eyes or skin
Contra-indications of Loratadine1. Allergy to drug or any other antihistamines
2. Stenosing peptic ulcer
3. Symptomatic prostatic hypertrophy
4. Asthmatic attack
5. Bladder neck obstruction
6. Pyloroduodenal obstruction
7. Narrow-angle glaucoma
Special Precautions while taking LoratadineUse with caution in patients with severe hepatic damage.Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationNEONATES- ContraindicatedIndications for Loratadine1. Allergic rhinitis (perennial and seasonal )
2. Vasomotor rhinitis
3. Allergic conjunctivitis
4. Urticaria( mild, uncomplicated )
5. Angioedema
6. Amelioration of allergic reactions to blood or plasma
7. Dermatographism
8. Adjunctive therapy in anaphylactic reactions
9. Decongestant
Interactions for LoratadineMacrolide antibiotics, ketoconazole, cimetidine, ranitidine and theophylline: Caution should be exerted while co-administration of these drugs which are known to inhibit hepatic metabolism.Typical Dosage for LoratadineOral-
General dose-
Adult-
10mg/day.
Children (>6) - Same as adult.
Schedule of LoratadineN/AStorage Requirements for LoratadineStore it at room temperature and away from excess heat and moisture.Effects of Missed Dosage of LoratadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of LoratadineGive symptomatic and supportive treatment. Induce emesis except in patients with impaired consciousness. Then administer activated charcoal to adsorb any remaining drug. Provide gastric lavage if emesis is contraindicated.Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Loratadine + Pseudoephedrine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including loratadine + pseudoephedrine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for loratadine + pseudoephedrine and other medicines and health products. Home delivery services for loratadine + pseudoephedrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take loratadine + pseudoephedrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for loratadine + pseudoephedrine before they complete the sale. You can get this information while placing the order for loratadine + pseudoephedrine with the pharmacy.
Loratadine + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for loratadine + pseudoephedrine might be better known than loratadine + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loratadine + pseudoephedrine in stock, you can ask for one of the branded alternatives for loratadine + pseudoephedrine.
