Phenylpropanolamine + Diphenylpyraline Pharmacology

Phenylpropanolamine + Diphenylpyraline

About Phenylpropanolamine + Diphenylpyraline
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Mechanism of Action of Phenylpropanolamine + Diphenylpyraline
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Pharmacokinets of Phenylpropanolamine + Diphenylpyraline
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Onset of Action for Phenylpropanolamine + Diphenylpyraline
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Duration of Action for Phenylpropanolamine + Diphenylpyraline
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Half Life of Phenylpropanolamine + Diphenylpyraline
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Side Effects of Phenylpropanolamine + Diphenylpyraline
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Contra-indications of Phenylpropanolamine + Diphenylpyraline
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Special Precautions while taking Phenylpropanolamine + Diphenylpyraline
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Phenylpropanolamine + Diphenylpyraline
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Interactions for Phenylpropanolamine + Diphenylpyraline
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Typical Dosage for Phenylpropanolamine + Diphenylpyraline
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Schedule of Phenylpropanolamine + Diphenylpyraline
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Storage Requirements for Phenylpropanolamine + Diphenylpyraline
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Effects of Missed Dosage of Phenylpropanolamine + Diphenylpyraline
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Effects of Overdose of Phenylpropanolamine + Diphenylpyraline
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Phenylpropanolamine

About Phenylpropanolamine
Alfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.
Mechanism of Action of Phenylpropanolamine
It is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus

Pharmacokinets of Phenylpropanolamine
Absorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.
Onset of Action for Phenylpropanolamine
15 to 30 minutes
Duration of Action for Phenylpropanolamine
3 hours
Half Life of Phenylpropanolamine
N/A
Side Effects of Phenylpropanolamine
1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. Seizures
Contra-indications of Phenylpropanolamine
1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine
1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Phenylpropanolamine
1. Nasal congestion

Interactions for Phenylpropanolamine
N/A
Typical Dosage for Phenylpropanolamine
Oral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day

Schedule of Phenylpropanolamine
H
Storage Requirements for Phenylpropanolamine
Store at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.
Effects of Missed Dosage of Phenylpropanolamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phenylpropanolamine
Provide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.

Diphenylpyraline

About Diphenylpyraline
First Generation H1 Antagonist ,Ethanolamine derivative,piperidine derivative, Antihistamine.
Mechanism of Action of Diphenylpyraline
Diphenylpyraline exerts its action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions.
Pharmacokinets of Diphenylpyraline
Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: It is metabolized in the liver.

Onset of Action for Diphenylpyraline
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Duration of Action for Diphenylpyraline
N/A
Half Life of Diphenylpyraline
N/A
Side Effects of Diphenylpyraline
1.Sedation
2.Inability to concentrate
3.Diminished alertness
4.Motor incordination
5.Fatigue
6.Insomnia
7.Somnolence
8.Dry mouth
9.Urinery hesitancy
10.Altered bowel movement.
Contra-indications of Diphenylpyraline
1.Cardiac and blood vessel diseases
2.Disorders of blood
3.Hypertrophy of prostate
4.Blockade of urinary tract or difficulty in urination
5.Epilepsy
6.Jaundice
7.Glaucoma
8.Hepatic impairment
9.Reye`s syndrome.
Special Precautions while taking Diphenylpyraline
1.Driving or any work requiring mental alertness
Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
N/A
Indications for Diphenylpyraline
1. As an ingredient in cough mixtures
Interactions for Diphenylpyraline
N/A
Typical Dosage for Diphenylpyraline
As directed by the Physician
Schedule of Diphenylpyraline
G
Storage Requirements for Diphenylpyraline
Store in a well closed container below 25 degree C.
Effects of Missed Dosage of Diphenylpyraline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diphenylpyraline
Provide symptomatic treatment and supportive measures.

Home Delivery for Phenylpropanolamine + Diphenylpyraline in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for phenylpropanolamine + diphenylpyraline and other medicines and health products. Home delivery services for phenylpropanolamine + diphenylpyraline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take phenylpropanolamine + diphenylpyraline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for phenylpropanolamine + diphenylpyraline before they complete the sale. You can get this information while placing the order for phenylpropanolamine + diphenylpyraline with the pharmacy.

Phenylpropanolamine + Diphenylpyraline is a generic medicine name and there are several brands available for it. Some of the brands for phenylpropanolamine + diphenylpyraline might be better known than phenylpropanolamine + diphenylpyraline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phenylpropanolamine + diphenylpyraline in stock, you can ask for one of the branded alternatives for phenylpropanolamine + diphenylpyraline.