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- Pharmacology For Phenylpropanolamine + Pheniramine Maleate
Phenylpropanolamine + Pheniramine Maleate Pharmacology
Phenylpropanolamine + Pheniramine Maleate
About Phenylpropanolamine + Pheniramine MaleateN/AMechanism of Action of Phenylpropanolamine + Pheniramine MaleateN/APharmacokinets of Phenylpropanolamine + Pheniramine MaleateN/AOnset of Action for Phenylpropanolamine + Pheniramine MaleateN/ADuration of Action for Phenylpropanolamine + Pheniramine MaleateN/AHalf Life of Phenylpropanolamine + Pheniramine MaleateN/ASide Effects of Phenylpropanolamine + Pheniramine MaleateN/AContra-indications of Phenylpropanolamine + Pheniramine MaleateN/ASpecial Precautions while taking Phenylpropanolamine + Pheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Phenylpropanolamine + Pheniramine MaleateN/AInteractions for Phenylpropanolamine + Pheniramine MaleateN/ATypical Dosage for Phenylpropanolamine + Pheniramine MaleateN/ASchedule of Phenylpropanolamine + Pheniramine MaleateN/AStorage Requirements for Phenylpropanolamine + Pheniramine MaleateN/AEffects of Missed Dosage of Phenylpropanolamine + Pheniramine MaleateN/AEffects of Overdose of Phenylpropanolamine + Pheniramine MaleateN/APhenylpropanolamine
About PhenylpropanolamineAlfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.Mechanism of Action of PhenylpropanolamineIt is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus
Pharmacokinets of PhenylpropanolamineAbsorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.Onset of Action for Phenylpropanolamine15 to 30 minutesDuration of Action for Phenylpropanolamine3 hoursHalf Life of PhenylpropanolamineN/ASide Effects of Phenylpropanolamine1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. SeizuresContra-indications of Phenylpropanolamine1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Phenylpropanolamine1. Nasal congestion
Interactions for PhenylpropanolamineN/ATypical Dosage for PhenylpropanolamineOral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day
Schedule of PhenylpropanolamineHStorage Requirements for PhenylpropanolamineStore at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.Effects of Missed Dosage of PhenylpropanolamineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylpropanolamineProvide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.
Pheniramine Maleate
About Pheniramine MaleateFirst generation HistamineH1 antagonist ,Alkylamine derivative, Anti histamine.Mechanism of Action of Pheniramine MaleateThis alkyl amine derivative has peripheral H1 receptor antagonist action and compete with histamine for binding to the receptors present on bronchi, uterus etc. This inhibits the activation of receptors and corresponding allergic symptoms produced by it. Centrally the drug also has some antimuscarinic activity.Pharmacokinets of Pheniramine MaleateN/AOnset of Action for Pheniramine MaleateN/ADuration of Action for Pheniramine MaleateN/AHalf Life of Pheniramine Maleate19 hrsSide Effects of Pheniramine Maleate1. Drowsiness
2. Nervousness
3. Irritability
4. Incoordination
5. Lack of concentration
6. Dizziness
7. Tinnitus
8. Nausea
9. Vomiting
10. Difficulty in passing urine
11. Asthma
12. Wheezing
13. Swelling of the face lips or tongue
14. Hives
15. Itching
16. Skin rash
17. Fainting
Contra-indications of Pheniramine Maleate1. Hypersensitivity to the drug or its ingredients
2. Porphyria
Special Precautions while taking Pheniramine Maleate1. Heart disease
2. High blood pressure
3. Narrow angle glaucoma
4. Enlarged prostate gland
5. Any work which require mental alertness
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Pheniramine Maleate1. Eczema
2. Dermatitis
3. Urticaria
4. Skin oedema
5. Itching due to insect bites
6. Photo-dermatitis
7. Rhinitis
8. Serum sickness
9. Paresis during pregnancy
10. Toxaemia and retention of placenta
11. Motion sickness
Interactions for Pheniramine MaleateAlcohol and other CNS depressants (Hypnotics, Sedative, Tranquilizers, Antianxiety agents, Narcotic analgesics): Additive effect leading to profound CNS depression.
MAOIs: Prolong anticholinergic (drying) effects.
Anticholinergics (some) & Tricyclic Antidepressants: May have enhanced effect.
Aminoglycosides: Ototoxicity of aminoglycosides masked.Typical Dosage for Pheniramine MaleateOral
Adult:15-30 mg 2 - 3 times daily.
Schedule of Pheniramine MaleateGStorage Requirements for Pheniramine MaleateStored at controlled room temperature. Protect from light and excessive heat. Keep out of reach of children.Effects of Missed Dosage of Pheniramine MaleateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Pheniramine MaleateGive symptomatic and supportive treatmentHome Delivery for Phenylpropanolamine + Pheniramine Maleate in Your City
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Phenylpropanolamine + Pheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for phenylpropanolamine + pheniramine maleate might be better known than phenylpropanolamine + pheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phenylpropanolamine + pheniramine maleate in stock, you can ask for one of the branded alternatives for phenylpropanolamine + pheniramine maleate.
