- Medicine India
- Generic Medicines
- Pharmacology For Protamine Sulphate
Protamine Sulphate Pharmacology
Protamine SulphateAbout Protamine SulphateA highly cationic peptide, Heparin antagonist, Heparin antidote,Antihaemorrhagic.Mechanism of Action of Protamine SulphateIt is a basic protein obtained from sperm of a fish and acts as a heparin antagonist. It neutralizes heparin in a weight for weight basis (1mg is needed for every 100U of heparin. In the presence of heparin the drug forms a salt that neutralizes the anticoagulant effects of both drugs.Pharmacokinets of Protamine SulphateAbsorption: Administered intravenously. Metabolism: the heparin-protamine complex formed is partly degradedOnset of Action for Protamine SulphateOne minuteDuration of Action for Protamine Sulphate2 hoursHalf Life of Protamine SulphateN/ASide Effects of Protamine Sulphate1.Hypotension
5.Feeling of warmth
9.Acute pulmonary hypertension
Contra-indications of Protamine SulphateHypersensitivity to the drugSpecial Precautions while taking Protamine Sulphate1.Avoid too rapid administration
3.Those who have previously treated with protamine
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be used.Breast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Protamine SulphateAntidote for heparinInteractions for Protamine SulphateN/ATypical Dosage for Protamine Sulphate1mg of drug neutralizes approximately 100 I.U. of heparin. Administered by slow I.V. injection over 1 to 3minutes
Maximum dose: 50mg in 10 minute period.
Schedule of Protamine SulphateCStorage Requirements for Protamine SulphateStore at room temperature at a range of 15 to 25degree C.Effects of Missed Dosage of Protamine SulphateThe doctor should be informed immediately if a dose is missed.Effects of Overdose of Protamine SulphateMonitor coagulation tests and respiratory function. Treatment is symptomatic. Replace blood loss with blood transfusion or fresh frozen plasma. If there is hypotension treat with fluids, epinephrine, dobutamine, or dopamine.
Home Delivery for Protamine Sulphate in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including protamine sulphate.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for protamine sulphate and other medicines and health products. Home delivery services for protamine sulphate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take protamine sulphate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for protamine sulphate before they complete the sale. You can get this information while placing the order for protamine sulphate with the pharmacy.
Protamine Sulphate is a generic medicine name and there are several brands available for it. Some of the brands for protamine sulphate might be better known than protamine sulphate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have protamine sulphate in stock, you can ask for one of the branded alternatives for protamine sulphate.