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- Pharmacology For Terfenadine + Pseudoephedrine
Terfenadine + Pseudoephedrine Pharmacology
Terfenadine + Pseudoephedrine
About Terfenadine + PseudoephedrineN/AMechanism of Action of Terfenadine + PseudoephedrineN/APharmacokinets of Terfenadine + PseudoephedrineN/AOnset of Action for Terfenadine + PseudoephedrineN/ADuration of Action for Terfenadine + PseudoephedrineN/AHalf Life of Terfenadine + PseudoephedrineN/ASide Effects of Terfenadine + PseudoephedrineN/AContra-indications of Terfenadine + PseudoephedrineN/ASpecial Precautions while taking Terfenadine + PseudoephedrineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Terfenadine + PseudoephedrineN/AInteractions for Terfenadine + PseudoephedrineN/ATypical Dosage for Terfenadine + PseudoephedrineN/ASchedule of Terfenadine + PseudoephedrineN/AStorage Requirements for Terfenadine + PseudoephedrineN/AEffects of Missed Dosage of Terfenadine + PseudoephedrineN/AEffects of Overdose of Terfenadine + PseudoephedrineN/ATerfenadine
About TerfenadineSecond generation histamine H1 antagonist, Benzhydryl derivative, Antihistamine.Mechanism of Action of TerfenadineTerfenadine competitively bind to the histamine H1-receptors on the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of terfenadine suppresses the formation of edema, flare, and pruritis resulting from histaminic activity. In large dose it also inhibits cardiac potassium channels.Pharmacokinets of TerfenadineAbsorption- Moderately absorbed after oral administration.
Distribution- Widely distributed in the body. 70% bound to the plasma Proteins.
Metabolism- Metabolized in the liver to its metabolites. Fexofenadine is its active metabolite.
Excretion- Excreted via urine and feces.
Onset of Action for Terfenadine1 - 2 hrDuration of Action for Terfenadine>12 hrHalf Life of Terfenadine3.5 hrsSide Effects of Terfenadine1. Difficulty breathing
2. Closing of throat
3. Swelling of lips, tongue, or face
4. Hives
5. Irregular heartbeat
6. Seizures
7. Drowsiness
8. Dizziness
9. Headache
10. Nervousness
11. Nausea
12. Diarrhea
13. Abdominal discomfort
14. Dry mouth
15. Dry skin
16. Itchiness
Contra-indications of Terfenadine1. Hypersensitivity to the drug
2. Severe hepatic dysfunction
Special Precautions while taking Terfenadine1. Liver disease
2. Asthma or other lung disease
3. Glaucoma
4. Enlarged prostate gland
5. Heart disease
6. High blood pressure
7. Overactive thyroid gland
8. Stomach ulcers
9. Urinary tract blockage
10. Kidney disease
11. Drug allergies
12. Any work which require mental alertness like driving and machine operations
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Terfenadine1. Rash
2. Hives
3. Watery eyes
4. Runny nose
5. Itching eyes
6. Sneezing.
7. Atopic dermatitis
8. Dermo-graphism
9. Common cold
10. Asthma (induced by atophy or exercise)
Interactions for TerfenadineItraconazole and other Azole - type antifungal agents (including Fluconazole, Metronidazole, Miconazole and Ketoconazole): QT interval prolongation and rare serious cardiac events like death, cardiac arrest and ventricular arrhythmias may occur because ketoconazole markedly inhibits metabolism of terfenadine. Hence concomitant administration of ketoconazole and terfenadine is contraindicated.
Macrolides (e.g. Erythomycin, Clarithromycin): Coadministration with terfenadine is contraindicated.
Alcohol, CNS depressants: Additive CNS depressant effects may occur.
Food: Reduces absorption.
Typical Dosage for TerfenadineOral- General Dose.
Adult-
60mg twice daily OR 120mg once daily.
Children-
For 3-5 yrs-15mg twice daily.
For 6-12 yrs- 30-60 mg twice daily.
Schedule of TerfenadineHStorage Requirements for TerfenadineStore at room temperature away from moisture and heat.Effects of Missed Dosage of TerfenadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TerfenadineGive symptomatic and supportive treatment.Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Terfenadine + Pseudoephedrine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for terfenadine + pseudoephedrine and other medicines and health products. Home delivery services for terfenadine + pseudoephedrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take terfenadine + pseudoephedrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for terfenadine + pseudoephedrine before they complete the sale. You can get this information while placing the order for terfenadine + pseudoephedrine with the pharmacy.
Terfenadine + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for terfenadine + pseudoephedrine might be better known than terfenadine + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have terfenadine + pseudoephedrine in stock, you can ask for one of the branded alternatives for terfenadine + pseudoephedrine.
