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- Pharmacology For Dextromethorphan + Terfenadine
Dextromethorphan + Terfenadine Pharmacology
Dextromethorphan + Terfenadine
About Dextromethorphan + TerfenadineN/AMechanism of Action of Dextromethorphan + TerfenadineN/APharmacokinets of Dextromethorphan + TerfenadineN/AOnset of Action for Dextromethorphan + TerfenadineN/ADuration of Action for Dextromethorphan + TerfenadineN/AHalf Life of Dextromethorphan + TerfenadineN/ASide Effects of Dextromethorphan + TerfenadineN/AContra-indications of Dextromethorphan + TerfenadineN/ASpecial Precautions while taking Dextromethorphan + TerfenadineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dextromethorphan + TerfenadineN/AInteractions for Dextromethorphan + TerfenadineN/ATypical Dosage for Dextromethorphan + TerfenadineN/ASchedule of Dextromethorphan + TerfenadineN/AStorage Requirements for Dextromethorphan + TerfenadineN/AEffects of Missed Dosage of Dextromethorphan + TerfenadineN/AEffects of Overdose of Dextromethorphan + TerfenadineN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Terfenadine
About TerfenadineSecond generation histamine H1 antagonist, Benzhydryl derivative, Antihistamine.Mechanism of Action of TerfenadineTerfenadine competitively bind to the histamine H1-receptors on the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of terfenadine suppresses the formation of edema, flare, and pruritis resulting from histaminic activity. In large dose it also inhibits cardiac potassium channels.Pharmacokinets of TerfenadineAbsorption- Moderately absorbed after oral administration.
Distribution- Widely distributed in the body. 70% bound to the plasma Proteins.
Metabolism- Metabolized in the liver to its metabolites. Fexofenadine is its active metabolite.
Excretion- Excreted via urine and feces.
Onset of Action for Terfenadine1 - 2 hrDuration of Action for Terfenadine>12 hrHalf Life of Terfenadine3.5 hrsSide Effects of Terfenadine1. Difficulty breathing
2. Closing of throat
3. Swelling of lips, tongue, or face
4. Hives
5. Irregular heartbeat
6. Seizures
7. Drowsiness
8. Dizziness
9. Headache
10. Nervousness
11. Nausea
12. Diarrhea
13. Abdominal discomfort
14. Dry mouth
15. Dry skin
16. Itchiness
Contra-indications of Terfenadine1. Hypersensitivity to the drug
2. Severe hepatic dysfunction
Special Precautions while taking Terfenadine1. Liver disease
2. Asthma or other lung disease
3. Glaucoma
4. Enlarged prostate gland
5. Heart disease
6. High blood pressure
7. Overactive thyroid gland
8. Stomach ulcers
9. Urinary tract blockage
10. Kidney disease
11. Drug allergies
12. Any work which require mental alertness like driving and machine operations
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Terfenadine1. Rash
2. Hives
3. Watery eyes
4. Runny nose
5. Itching eyes
6. Sneezing.
7. Atopic dermatitis
8. Dermo-graphism
9. Common cold
10. Asthma (induced by atophy or exercise)
Interactions for TerfenadineItraconazole and other Azole - type antifungal agents (including Fluconazole, Metronidazole, Miconazole and Ketoconazole): QT interval prolongation and rare serious cardiac events like death, cardiac arrest and ventricular arrhythmias may occur because ketoconazole markedly inhibits metabolism of terfenadine. Hence concomitant administration of ketoconazole and terfenadine is contraindicated.
Macrolides (e.g. Erythomycin, Clarithromycin): Coadministration with terfenadine is contraindicated.
Alcohol, CNS depressants: Additive CNS depressant effects may occur.
Food: Reduces absorption.
Typical Dosage for TerfenadineOral- General Dose.
Adult-
60mg twice daily OR 120mg once daily.
Children-
For 3-5 yrs-15mg twice daily.
For 6-12 yrs- 30-60 mg twice daily.
Schedule of TerfenadineHStorage Requirements for TerfenadineStore at room temperature away from moisture and heat.Effects of Missed Dosage of TerfenadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TerfenadineGive symptomatic and supportive treatment.Home Delivery for Dextromethorphan + Terfenadine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextromethorphan + terfenadine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextromethorphan + terfenadine and other medicines and health products. Home delivery services for dextromethorphan + terfenadine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take dextromethorphan + terfenadine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + terfenadine before they complete the sale. You can get this information while placing the order for dextromethorphan + terfenadine with the pharmacy.
Dextromethorphan + Terfenadine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + terfenadine might be better known than dextromethorphan + terfenadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + terfenadine in stock, you can ask for one of the branded alternatives for dextromethorphan + terfenadine.
