Codeine + Pheniramine Maleate Pharmacology

Codeine + Pheniramine Maleate

About Codeine + Pheniramine Maleate
N/A
Mechanism of Action of Codeine + Pheniramine Maleate
N/A
Pharmacokinets of Codeine + Pheniramine Maleate
N/A
Onset of Action for Codeine + Pheniramine Maleate
N/A
Duration of Action for Codeine + Pheniramine Maleate
N/A
Half Life of Codeine + Pheniramine Maleate
N/A
Side Effects of Codeine + Pheniramine Maleate
N/A
Contra-indications of Codeine + Pheniramine Maleate
N/A
Special Precautions while taking Codeine + Pheniramine Maleate
N/A
Pregnancy Related Information
Contraindicated; since Codeine and Pheniramine Maleate are contraindicated in pregnancy, the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Pheniramine Maleate is contraindicated in breast feeding; the combination generic cannot be used in breast feeding mother
Children Related Information
N/A
Indications for Codeine + Pheniramine Maleate
It is a combination of antitussive Codeine and decongestant Pheniramine Maleate.
Cough
Interactions for Codeine + Pheniramine Maleate
N/A
Typical Dosage for Codeine + Pheniramine Maleate
5 ml to be taken 3 times daily.
Schedule of Codeine + Pheniramine Maleate
N/A
Storage Requirements for Codeine + Pheniramine Maleate
N/A
Effects of Missed Dosage of Codeine + Pheniramine Maleate
N/A
Effects of Overdose of Codeine + Pheniramine Maleate
N/A

Codeine

About Codeine
An opiate, methylmorphine , Narcotic analgesic, antitussive, and antidiarrheal.
Mechanism of Action of Codeine
Codeine exerts it`s action through opioid receptors and posses antitussive properties. It selectively and directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptors.
Pharmacokinets of Codeine
Absorption: Well absorbed after oral and parenteral administration. Distribution: Widely distributed in the body; it crosses placenta and also enters in to the breast milk. Metabolism: Metabolized in the liver by demethylation and glucuronide conjugation, Excretion: Excreted mainly in the urine as nor codeine and free and conjugated morphine.
Onset of Action for Codeine
Oral: 30 to 45 minutes
I.V.: Rapid
I.M.: 10 to 30 minutes
S.C.: 10 to 30 minutes
Duration of Action for Codeine
Oral: 4 to 6 hours
I.V.: 4 to 6 hours
I.M.: 4 to 6 hours
S.C.: 4 to 6 hours
Half Life of Codeine
N/A
Side Effects of Codeine
1. Constipation
2. Nausea
3. Vomiting
4. Drymouth
5. Respiratory depression
6. Hypotension
7. Bradycardia
8. Dizziness
9. Sedation
10. Euphoria
11. Urine retention
12. Flushing
13. Pruritus
14. Diaphoresis
15. Physical dependence.
Contra-indications of Codeine
1. Hypersensitivity to the drug
2. Bronchial asthma
3. Increased intracranial pressure
4. Respiratory depression
5. Paralytic ileus
6. Head injury
7. Alcoholism
8. Diverticulitis
9. Following bowel surgery.
Special Precautions while taking Codeine
1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
4. Hypothyroidism
5. Addison`s disease
6. COPD
7. In deliberate individuals
8. Prostatic hypertrophy
9. Epilepsy
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Codeine
1. Nonproductive cough
2. Mild to moderate pain.
Interactions for Codeine
N/A
Typical Dosage for Codeine
Adults:
Oral:
Nonproductive cough:10 to 20mg 4 times daily;Maximum dose: 120mg/day
Oral, S.C., I.M.:
Mild to moderate pain:15 to 60mg Orally, S.C., or I.M.;4 to 6 times daily as required by the patient.

Children:
Oral:
Nonproductive cough:
Over 12 years: 10 to 20mg 4 times daily
Age 6 to 12: 5 to 10mg 4 times daily;Maximum dose: 60mg/day
Age 2 to 6: 1mg/kg/day as four equally divided doses and do not exceed 30mg in 24 hours.
Oral, S.C., I.M.:
Mild to moderate pain:0.5mg/kg orally every 4 to 6 hours or 0.5mg/kg S.C. or I.M.
Schedule of Codeine
H
Storage Requirements for Codeine
Store at controlled room temperature at a range of 15 to 30 degree C and protects from light.
Effects of Missed Dosage of Codeine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Codeine
Establish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.

Pheniramine Maleate

About Pheniramine Maleate
First generation HistamineH1 antagonist ,Alkylamine derivative, Anti histamine.
Mechanism of Action of Pheniramine Maleate
This alkyl amine derivative has peripheral H1 receptor antagonist action and compete with histamine for binding to the receptors present on bronchi, uterus etc. This inhibits the activation of receptors and corresponding allergic symptoms produced by it. Centrally the drug also has some antimuscarinic activity.
Pharmacokinets of Pheniramine Maleate
N/A
Onset of Action for Pheniramine Maleate
N/A
Duration of Action for Pheniramine Maleate
N/A
Half Life of Pheniramine Maleate
19 hrs
Side Effects of Pheniramine Maleate
1. Drowsiness
2. Nervousness
3. Irritability
4. Incoordination
5. Lack of concentration
6. Dizziness
7. Tinnitus
8. Nausea
9. Vomiting
10. Difficulty in passing urine
11. Asthma
12. Wheezing
13. Swelling of the face lips or tongue
14. Hives
15. Itching
16. Skin rash
17. Fainting
Contra-indications of Pheniramine Maleate
1. Hypersensitivity to the drug or its ingredients
2. Porphyria
Special Precautions while taking Pheniramine Maleate
1. Heart disease
2. High blood pressure
3. Narrow angle glaucoma
4. Enlarged prostate gland
5. Any work which require mental alertness
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Pheniramine Maleate
1. Eczema
2. Dermatitis
3. Urticaria
4. Skin oedema
5. Itching due to insect bites
6. Photo-dermatitis
7. Rhinitis
8. Serum sickness
9. Paresis during pregnancy
10. Toxaemia and retention of placenta
11. Motion sickness
Interactions for Pheniramine Maleate
Alcohol and other CNS depressants (Hypnotics, Sedative, Tranquilizers, Antianxiety agents, Narcotic analgesics): Additive effect leading to profound CNS depression.
MAOIs: Prolong anticholinergic (drying) effects.
Anticholinergics (some) & Tricyclic Antidepressants: May have enhanced effect.
Aminoglycosides: Ototoxicity of aminoglycosides masked.
Typical Dosage for Pheniramine Maleate
Oral
Adult:15-30 mg 2 - 3 times daily.

Schedule of Pheniramine Maleate
G
Storage Requirements for Pheniramine Maleate
Stored at controlled room temperature. Protect from light and excessive heat. Keep out of reach of children.
Effects of Missed Dosage of Pheniramine Maleate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pheniramine Maleate
Give symptomatic and supportive treatment

Home Delivery for Codeine + Pheniramine Maleate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for codeine + pheniramine maleate and other medicines and health products. Home delivery services for codeine + pheniramine maleate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take codeine + pheniramine maleate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for codeine + pheniramine maleate before they complete the sale. You can get this information while placing the order for codeine + pheniramine maleate with the pharmacy.

Codeine + Pheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for codeine + pheniramine maleate might be better known than codeine + pheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have codeine + pheniramine maleate in stock, you can ask for one of the branded alternatives for codeine + pheniramine maleate.