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- Pharmacology For Dextromethorphan + Cetirizine
Dextromethorphan + Cetirizine Pharmacology
Dextromethorphan + Cetirizine
About Dextromethorphan + CetirizineN/AMechanism of Action of Dextromethorphan + CetirizineN/APharmacokinets of Dextromethorphan + CetirizineN/AOnset of Action for Dextromethorphan + CetirizineN/ADuration of Action for Dextromethorphan + CetirizineN/AHalf Life of Dextromethorphan + CetirizineN/ASide Effects of Dextromethorphan + CetirizineN/AContra-indications of Dextromethorphan + CetirizineN/ASpecial Precautions while taking Dextromethorphan + CetirizineN/APregnancy Related InformationContraindicated; since Dextromethorphan and Cetirizine are contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Dextromethorphan and Cetirizine are contraindicated in lactation, the combination generic cannot be used in breast feeding motherChildren Related InformationN/AIndications for Dextromethorphan + Cetirizine1.Cough
2.Throat smoothening
3.Condition where retention of sputum is a problem
Interactions for Dextromethorphan + CetirizineN/ATypical Dosage for Dextromethorphan + CetirizineAdult - 1 to 2 teaspoonfuls to be taken 4 times a day
Children (6 to 12 years) - 1 teaspoonful to be taken 3 - 4 times daily
Schedule of Dextromethorphan + CetirizineN/AStorage Requirements for Dextromethorphan + CetirizineN/AEffects of Missed Dosage of Dextromethorphan + CetirizineN/AEffects of Overdose of Dextromethorphan + CetirizineN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Cetirizine
About CetirizineSecond Generation H1 Antagonist, Metabolite of hydroxyzine, Antihistamine.Mechanism of Action of CetirizineThis drug is a selective peripheral H1 receptor antagonist. Thus it inhibits the allergic symptoms produced by histamines like cold, rhinorrhea, sneezing, urticaria etc. The drug has some mast cell stabilizing properties. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.Pharmacokinets of CetirizineAbsorption- Well absorbed after oral administration
Distribution-Widely distributed in the body. 93% bound to the plasma proteins. It enters to the CNS in small amounts.
Metabolism-Metabolized in the liver to its metabolites by oxidative O-dealkylation
Excretion- Excreted through urine (50% as unchanged form) and a small amount through feces
Onset of Action for Cetirizine10-30 minDuration of Action for Cetirizine12-24hrsHalf Life of CetirizineIts plasma half life is 8.3 hrsSide Effects of Cetirizine1. Somnolence.
2. Fatigue
3. Malaise
4. Headache
5. Dry mouth
6. CNS stimulation in children
7. Dizziness
8. Tinnitus
9. Incordination
10. Blurred vision
12. Diplopia
13. Euphoria
14. Nervousness
15. Drowsiness
16. Excessive tiredness
17. Vomiting
18. Diarrhea
19. Sore throat
20. Stomach pain
Contra-indications of CetirizineHypersensitivity to the drug or hydroxyzine.Special Precautions while taking Cetirizine1. Renal impairment.
2. Hepatic dysfunction.
3. Haemodialysis.
4. Any work which require mental alertness like driving or machine operation.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Cetirizine1. Sneezing
2. Rhinorrhoea
3. Postnasal discharge.
4. Common coughs
5. Colds.
6. Chronic urticaria
7. Dermatitis
8. Pruritic skin disorders
9. Hay fever
10. Angioedema
Interactions for CetirizineAlcohol: Avoid excessive alcohol consumption.Typical Dosage for CetirizineOral-
Adult - 10 mg daily, single dose
Children (6-12 years) -5 mg daily.
Schedule of CetirizineN/AStorage Requirements for CetirizineStore in cool, dry, dark placeEffects of Missed Dosage of CetirizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CetirizineGive symptomatic and supportive treatment.Home Delivery for Dextromethorphan + Cetirizine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextromethorphan + cetirizine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextromethorphan + cetirizine and other medicines and health products. Home delivery services for dextromethorphan + cetirizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take dextromethorphan + cetirizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + cetirizine before they complete the sale. You can get this information while placing the order for dextromethorphan + cetirizine with the pharmacy.
Dextromethorphan + Cetirizine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + cetirizine might be better known than dextromethorphan + cetirizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + cetirizine in stock, you can ask for one of the branded alternatives for dextromethorphan + cetirizine.
