Polystrene sulphonate resin Pharmacology

Polystrene sulphonate resin

About Polystrene sulphonate resin
Insoluble cation exchange resins, Potassium binder , Potassium removal Agents( In Hyperkalemia).
Mechanism of Action of Polystrene sulphonate resin
These are insoluble cation exchange resins used for potassium removal. The resin acts by cumulative process throughout the gastrointestinal tract, removing potassium ions which are carried away in the feces. As the resin passes through the large intestine and colon, it comes into contact with fluids containing increasing amounts of potassium. Potassium is taken up in increasing amounts in exchange for calcium or sodium ions. As the length of time the resin remains in the body increases the effectiveness of resin.
Pharmacokinets of Polystrene sulphonate resin
Absorption: It is not absorbed from the gastrointestinal tract. Excretion: Excreted through faeces.
Onset of Action for Polystrene sulphonate resin
Duration of Action for Polystrene sulphonate resin
Half Life of Polystrene sulphonate resin
Side Effects of Polystrene sulphonate resin
1. Nausea
2. Vomiting
3. Anorexia
4. Gastrointestinal irritation
5. Sodium retention
6. Hypomagnesemia
7. Diarrhoea
8. Rectal ulceration (following rectal enema)
9. Constipation
10. Hypercalcaemia
Contra-indications of Polystrene sulphonate resin
1.Hypersensitivity to polystyrene sulfonate resins
2.Patients with: serum potassium <5 mmol/l
3.Conditions associated with hypercalcaemia (e.g., hyperparathyroidism, multiple myeloma, sarcoidosis or metastic carcinoma)
4.Obstructive bowel disease
5.Oral administration is contraindicated in neonates
6. Administration of the resin in neonates with reduced gut motility
Special Precautions while taking Polystrene sulphonate resin
1. Monitor fluid and electrolyte disturbances
2. Sodium containing resins in congestive heart failure
3. Renal impairment
4. Oedema
5. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Neonates: Oral form is contraindicated
Indications for Polystrene sulphonate resin
1. Hyperkalaemia, associated with anuria or severe oliguria; and dialysis patient.
Interactions for Polystrene sulphonate resin
Typical Dosage for Polystrene sulphonate resin
Oral: 15g in water or as paste 3 to 4 times in a day.
It should not be given in fruit drinks and some carbonated beverages, since these have high potassium content.
Children: 0.5 to 1g /kg/day in divided doses.
Rectal enema:
Adults: As a suspension of 30 g resin in 100 ml of 2% methylcellulose and 100 ml of water. To be retained for 9 hours to increase effectiveness.
Schedule of Polystrene sulphonate resin
Storage Requirements for Polystrene sulphonate resin
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Polystrene sulphonate resin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Polystrene sulphonate resin
Appropriate measures should be taken to correct serum electrolytes (potassium, calcium). The resin should be removed from the alimentary tract by appropriate use of laxatives or enemas.

Home Delivery for Polystrene sulphonate resin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including polystrene sulphonate resin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for polystrene sulphonate resin and other medicines and health products. Home delivery services for polystrene sulphonate resin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take polystrene sulphonate resin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for polystrene sulphonate resin before they complete the sale. You can get this information while placing the order for polystrene sulphonate resin with the pharmacy.

Polystrene sulphonate resin is a generic medicine name and there are several brands available for it. Some of the brands for polystrene sulphonate resin might be better known than polystrene sulphonate resin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have polystrene sulphonate resin in stock, you can ask for one of the branded alternatives for polystrene sulphonate resin.