Dextromethorphan + Phenylpropanolamine + Triprolidine Pharmacology

Dextromethorphan + Phenylpropanolamine + Triprolidine

About Dextromethorphan + Phenylpropanolamine + Triprolidine
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Mechanism of Action of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Pharmacokinets of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Onset of Action for Dextromethorphan + Phenylpropanolamine + Triprolidine
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Duration of Action for Dextromethorphan + Phenylpropanolamine + Triprolidine
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Half Life of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Side Effects of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Contra-indications of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Special Precautions while taking Dextromethorphan + Phenylpropanolamine + Triprolidine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dextromethorphan + Phenylpropanolamine + Triprolidine
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Interactions for Dextromethorphan + Phenylpropanolamine + Triprolidine
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Typical Dosage for Dextromethorphan + Phenylpropanolamine + Triprolidine
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Schedule of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Storage Requirements for Dextromethorphan + Phenylpropanolamine + Triprolidine
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Effects of Missed Dosage of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Effects of Overdose of Dextromethorphan + Phenylpropanolamine + Triprolidine
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Dextromethorphan

About Dextromethorphan
A synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.
Mechanism of Action of Dextromethorphan
Dextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))
Pharmacokinets of Dextromethorphan
Absorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.
Onset of Action for Dextromethorphan
Below ? an hour
Duration of Action for Dextromethorphan
3 to 6 hours
Half Life of Dextromethorphan
11 hours
Side Effects of Dextromethorphan
1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.
Contra-indications of Dextromethorphan
Patients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.
Special Precautions while taking Dextromethorphan
1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
May be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for Dextromethorphan
Chronic nonproductive cough.
Interactions for Dextromethorphan
N/A
Typical Dosage for Dextromethorphan
Oral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of Dextromethorphan
N/A
Storage Requirements for Dextromethorphan
Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Dextromethorphan
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dextromethorphan
Remove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.

Phenylpropanolamine

About Phenylpropanolamine
Alfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.
Mechanism of Action of Phenylpropanolamine
It is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus

Pharmacokinets of Phenylpropanolamine
Absorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.
Onset of Action for Phenylpropanolamine
15 to 30 minutes
Duration of Action for Phenylpropanolamine
3 hours
Half Life of Phenylpropanolamine
N/A
Side Effects of Phenylpropanolamine
1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. Seizures
Contra-indications of Phenylpropanolamine
1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine
1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Phenylpropanolamine
1. Nasal congestion

Interactions for Phenylpropanolamine
N/A
Typical Dosage for Phenylpropanolamine
Oral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day

Schedule of Phenylpropanolamine
H
Storage Requirements for Phenylpropanolamine
Store at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.
Effects of Missed Dosage of Phenylpropanolamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phenylpropanolamine
Provide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.

Triprolidine

About Triprolidine
First generation histamine H1 antagonist, Alkylamine derivative, Antihistamine.
Mechanism of Action of Triprolidine
Triprolidine hydrochloride exerts it`s action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions

Pharmacokinets of Triprolidine
Pharmacokinetics: Absorption: Well absorbed orally, Distribution: Widely distributed in the body, Metabolism: Metabolized in the body by carboxylation in to metabolites,
Excretion: Excreted through urine.
Onset of Action for Triprolidine
N/A
Duration of Action for Triprolidine
N/A
Half Life of Triprolidine
N/A
Side Effects of Triprolidine
1. Sedation
2. Inability to concentrate
3. Diminished alertness
4. Motor incordination
5. Fatigue
6. Insomnia
7. Somnolence
8. Dry mouth
9. Urinery hesitancy
10. Alterd bowel movement
11. Orthostatic hypotension
12. Palpitations
13. Tachycardia
14. Drowsiness
15. Dizziness
16. Excitation
17. Headache
18. Nervousness
19. Blurred vision
20. Nasal stuffiness
21. Anorexia
22. Epigastric distress
23. Nausea
24. Vomiting
25. Diarrhea
26. Constipation
27. Thickening of bronchial secretions
Contra-indications of Triprolidine
1. Hypersensitivity to the drug
2. Coronary insufficiency
3. Hypertension
4. Prostatism
5. Thyrotoxicosis
6. Bladder dysfunction
7. Narrow angle glaucoma
8. Phaeochromocytoma
9. Asthma
Special Precautions while taking Triprolidine
1. Driving or any work requiring mental alertness
2. Peptic ulcer
3. Pyloroduodenal obstruction
4. Prostatic hypertrophy
5. Bladder neck obstruction
6. Urinary retention
7. Increased intraocular pressure
8. Hyperthyroidism
9. Sleep apnea
10. Cardiovascular disease
11. Along with other medication

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Triprolidine
1. Common cold
2. Allergic respiratory diseases
3. Runny nose
4. Sneezing
5. Itchy nose and throat
6. Itchy,watery eyes
7. Cough
Interactions for Triprolidine
N/A
Typical Dosage for Triprolidine
Oral: 2.5 to 5mg dosage forms are available
Schedule of Triprolidine
G
Storage Requirements for Triprolidine
Store at room temperature at a range of 15 to 30 degree C. Protect from light, heat, and moisture.
Effects of Missed Dosage of Triprolidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Triprolidine
Provide symptomatic treatment and supportive measures.

Home Delivery for Dextromethorphan + Phenylpropanolamine + Triprolidine in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextromethorphan + phenylpropanolamine + triprolidine and other medicines and health products. Home delivery services for dextromethorphan + phenylpropanolamine + triprolidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dextromethorphan + phenylpropanolamine + triprolidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + phenylpropanolamine + triprolidine before they complete the sale. You can get this information while placing the order for dextromethorphan + phenylpropanolamine + triprolidine with the pharmacy.

Dextromethorphan + Phenylpropanolamine + Triprolidine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + phenylpropanolamine + triprolidine might be better known than dextromethorphan + phenylpropanolamine + triprolidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + phenylpropanolamine + triprolidine in stock, you can ask for one of the branded alternatives for dextromethorphan + phenylpropanolamine + triprolidine.