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- Pharmacology For Methocarbamol + Ibuprofen
Methocarbamol + Ibuprofen Pharmacology
Methocarbamol + Ibuprofen
About Methocarbamol + IbuprofenN/AMechanism of Action of Methocarbamol + IbuprofenN/APharmacokinets of Methocarbamol + IbuprofenN/AOnset of Action for Methocarbamol + IbuprofenN/ADuration of Action for Methocarbamol + IbuprofenN/AHalf Life of Methocarbamol + IbuprofenN/ASide Effects of Methocarbamol + IbuprofenN/AContra-indications of Methocarbamol + IbuprofenN/ASpecial Precautions while taking Methocarbamol + IbuprofenN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methocarbamol + IbuprofenN/AInteractions for Methocarbamol + IbuprofenN/ATypical Dosage for Methocarbamol + IbuprofenN/ASchedule of Methocarbamol + IbuprofenN/AStorage Requirements for Methocarbamol + IbuprofenN/AEffects of Missed Dosage of Methocarbamol + IbuprofenN/AEffects of Overdose of Methocarbamol + IbuprofenN/AMethocarbamol
About MethocarbamolA centrally acting skeletal muscle relaxant, Carbamate derivative, Skeletal muscle relaxant.Mechanism of Action of MethocarbamolThis skeletal muscle relaxant depresses central nervous system by the preferential blockade of spinal and supraspinal polysynaptic reflexes. This leads to sedation and a reduction in skeletal muscle spasms. These effects are accompanied by relief of pain and an increase in the mobility of the affected muscles. Pain relief is postulated to be due to alterations in the perception of pain.Pharmacokinets of MethocarbamolAbsorption- Rapidly and completely absorbed after administration
Distribution- Widely distributed throughout the body. It crosses the placenta
Metabolism- Extensively metabolized in the liver to its metabolites, by dealkylation and hydroxylation
Excretion- Drug and its metabolites are excreted rapidly and completely in urineOnset of Action for Methocarbamol30 minutes after oral administration
Immediate after IV administration
Duration of Action for Methocarbamol4-6 hoursHalf Life of Methocarbamol0.9 to 2.2 hoursSide Effects of Methocarbamol1. Drowsiness
2. Dizziness
3. Upset stomach
4. Blurred vision
5. Fever
6. Rash
7. Itching
8. Dyspepsia
9. Jaundice
10. Nausea
11. Vomiting
12. Leucopenia
Contra-indications of Methocarbamol1. Hypersensitive to methocarbamol or to any of the tablet components
2. Epilepsy
3. Coma or pre-coma
4. Myasthenia gravis
Special Precautions while taking Methocarbamol1. Alcohol abuse
2. CNS depressants therapy
3. Impairment of hepatic function
4. Renal impairment
5. Any work which require mental alertness such as driving or operating machine
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Methocarbamol1. Skeletal muscle spasm
2. Surgery
3. Orthopedic procedure
4. Neurological diseases
5. TetanusInteractions for MethocarbamolAlcohol and other CNS depressant drugs: CNS depressant effect potentiated.
Anorectics and anticholinergics: Efficacy increased by methocarbamol.
Lab tests: Causes colour interference in certain screening tests for 5-hydroxy-indoleacetic acid (5-HIAA) and Vanillyl mandelic acid (VMA).Typical Dosage for MethocarbamolAdults-
Oral-
500 mg -initial dosage, 3 tablets 4 times daily
Maintenance dosage- 2 tablets 4 times daily
750 mg - initial dosage, 2 tablets 4 times daily
Maintenance dosage, 1 tablet q.4 h, or 2 tablets 3 times daily
Intravenous-
Tetanus-
2-3g over 10-15 minutes
Then 2g ampules every 6 hours until oral therapy can be started by dose of 18-40 tablets of 500mg daily in divided doses, 4-6 hourly by nasogastric tube.
Children-
Initial dose -15mg / kg. Repeat every 6 hours.
Schedule of MethocarbamolHStorage Requirements for MethocarbamolStore at room temperature away from heat and direct light. Keep out of the reach of children.Effects of Missed Dosage of MethocarbamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MethocarbamolGive symptomatic and supportive treatment. Induce emesis or gastric lavage. Monitor urine output and vital signs regularlyIbuprofen
About IbuprofenNSAID, a propionic acid derivative, Analgesic and anti-inflammatory.Mechanism of Action of IbuprofenIbuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.Pharmacokinets of IbuprofenAbsorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.Onset of Action for Ibuprofen? hoursDuration of Action for Ibuprofen4-6 hours.Half Life of Ibuprofen2 hoursSide Effects of Ibuprofen1.Nausea
2.Vomiting
3.Diarrhoea
4.Gastrointestinal bleeding
5.Abdominal distress
6.Constipation
7.Peptic ulcer
8.Dyspepsia
9.Headache
10.Drowsiness
11.Blurring of vision
12.Tinnitus
13.Depression
14.Thrombocytopenia
15.Rash
16.Pruritis
Contra-indications of Ibuprofen1.Hypersensitivity to Ibuprofen and other NSAIDs
2.Peptic ulcer
Special Precautions while taking Ibuprofen1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Bleeding disorders
7.Phenylketonuria
8.Oedema
9.Heart failure
10.Myocardial infarction
11.Stroke
Pregnancy Related InformationUse with caution
PREGNANCY in third trimester: contraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
CHILDREN below 6 months: contraindicatedIndications for Ibuprofen1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
7.Dysmenorrhoea
8.Juvenile arthritis
9.Migraine
10.Patent ductus arteriosus(IV)
Interactions for IbuprofenN/ATypical Dosage for IbuprofenAdult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day
Schedule of IbuprofenHStorage Requirements for IbuprofenStore Ibuprofen at 15-30 degree C in a tightly closed light resistant container.Effects of Missed Dosage of IbuprofenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of IbuprofenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.Home Delivery for Methocarbamol + Ibuprofen in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for methocarbamol + ibuprofen and other medicines and health products. Home delivery services for methocarbamol + ibuprofen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take methocarbamol + ibuprofen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for methocarbamol + ibuprofen before they complete the sale. You can get this information while placing the order for methocarbamol + ibuprofen with the pharmacy.
Methocarbamol + Ibuprofen is a generic medicine name and there are several brands available for it. Some of the brands for methocarbamol + ibuprofen might be better known than methocarbamol + ibuprofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have methocarbamol + ibuprofen in stock, you can ask for one of the branded alternatives for methocarbamol + ibuprofen.