Desonide Pharmacology

Desonide

About Desonide
A synthetic nonfluorinated topical adrenocorticoid, Antipruritic, anti-inflammatory, antipsoriatic.
Mechanism of Action of Desonide
Desonide is a low potency topical steroid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Desonide
Absorption: Desonide is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier. Absorption is increased in inflammation, occlusion and skin damage.
Onset of Action for Desonide
N/A
Duration of Action for Desonide
N/A
Half Life of Desonide
N/A
Side Effects of Desonide
1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
12.Dry skin
13.Acne
14.Hypertrichosis
15.Folliculitis


Contra-indications of Desonide
1.Hypersensitivity to Desonide and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
5 Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Desonide
1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7.Withdraw gradually after prolonged use
8.For external use only
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Desonide
1.Otitis externa
2 Eczema
3.Dermatoses (secondary infected)
4.Psoriasis
5.Neuro dermatitis
6.Intertrigo
7.Lichen planus
8.Anal and vulval pruritis

Interactions for Desonide
N/A
Typical Dosage for Desonide
Topical: Desonide 0.05 % w/w cream and lotion is used
Clean the affected area and wash with warm water and then dry. Apply 2 - 4 times daily with gentle massage for 2 weeks.

Schedule of Desonide
N/A
Storage Requirements for Desonide
Store at room temperature. Protect from heat and light. Keep the container tightly closed. Keep out of the reach of children
Effects of Missed Dosage of Desonide
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Desonide
Give supportive measures and symptomatic treatment.

Home Delivery for Desonide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including desonide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for desonide and other medicines and health products. Home delivery services for desonide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take desonide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for desonide before they complete the sale. You can get this information while placing the order for desonide with the pharmacy.

Desonide is a generic medicine name and there are several brands available for it. Some of the brands for desonide might be better known than desonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have desonide in stock, you can ask for one of the branded alternatives for desonide.