Fluticasone + Azelastine Pharmacology

Fluticasone + Azelastine

About Fluticasone + Azelastine
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Mechanism of Action of Fluticasone + Azelastine
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Pharmacokinets of Fluticasone + Azelastine
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Onset of Action for Fluticasone + Azelastine
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Duration of Action for Fluticasone + Azelastine
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Half Life of Fluticasone + Azelastine
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Side Effects of Fluticasone + Azelastine
1.Dysgeusia
2.Epistaxis
3.Headache
Contra-indications of Fluticasone + Azelastine
N/A
Special Precautions while taking Fluticasone + Azelastine
1.Somnolence: Avoid engaging in hazardous occupations requiring complete mental alertness such as driving or operating machinery when taking Nasal Spray
2.Avoid concurrent use of alcohol or other central nervous system (CNS) depressants with Nasal Spray because further decreased alertness and impairment of CNS performance may occur
3.Epistaxis, nasal ulcerations, nasal septal perforation, impaired wound healing, Candida albicans infection. Monitor patients periodically for signs of adverse effects on the nasal mucosa. Avoid use in patients with recent nasal ulcers, nasal surgery, or nasal trauma
4.Development of glaucoma or posterior subcapsular cataracts. Monitor patients closely with a change in vision or with a history of increased intraocular pressure, glaucoma, and/or cataracts
5.Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex. More serious or even fatal course of chickenpox or measles in susceptible patients. Use caution in patients with the above because of the potential for worsening of these infections
6.Hypercorticism and adrenal suppression with very high dosages or at the regular dosage in susceptible individuals. If such changes occur, discontinue Nasal Spray slowly
7.Potential reduction in growth velocity in children. Monitor growth routinely in pediatric patients receiving Nasal Spray
Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Fluticasone + Azelastine
Relief of symptoms of seasonal allergic rhinitis in patients 12 years of age and older who require treatment with both azelastine hydrochloride and fluticasone propionate for symptomatic relief.
Interactions for Fluticasone + Azelastine
1.Potent inhibitors of cytochrome P450 (CYP) 3A4: May increase blood levels of fluticasone propionate
2.Ritanovir: Coadministration is not recommended
3.Other potent CYP3A4 inhibitors, such as ketoconazole: use caution with coadministration
Typical Dosage for Fluticasone + Azelastine
Recommended dose is 1 spray per nostril twice daily in adults and adolescents 12 years of age and older.
Schedule of Fluticasone + Azelastine
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Storage Requirements for Fluticasone + Azelastine
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Effects of Missed Dosage of Fluticasone + Azelastine
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Effects of Overdose of Fluticasone + Azelastine
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Fluticasone

About Fluticasone
Synthetic topical glucocorticoid, Anti inflammatory and antipruritic in corticosteroid-responsive dermatoses; atopic dermatitis.
Mechanism of Action of Fluticasone
It reduces prostaglandin synthesis by inhibiting cyclo oxygenase enzymes both COX1 and COX2.In higher doses it reduces the thromboxane A2 synthesis by COX1 inhibition. So platelet aggregation is inhibited by this drug. After topical application in the case of ophthalmic preparation it prevents miosis by reducing ocular prostaglandins synthesis. It is a phenylalkalonic acid derivative Non Steroidal Anti Inflammatory Drug.
Pharmacokinets of Fluticasone
Absorption- Well absorbed orally.
Distribution-99% bound to the plasma proteins.
Metabolism- In liver it is metabolized by hydroxylation and conjugation.
Excretion-It is excreted through urine.
Onset of Action for Fluticasone
30-60min
Duration of Action for Fluticasone
8-12hrs
Half Life of Fluticasone
6-10 hrs
Side Effects of Fluticasone
1. Anxiety
2. Insomnia
3. Tremors
4. Depression
5. Heart failure
6. Visual changes
7. Renal failure
8. Thrombocytopenia
9. Aplastic anemia
10. Photosensitivity
11. Urticaria
12. Angioedema


Contra-indications of Fluticasone
1. Hypersensitivity to this drug
2. Peptic ulcer
3. Gastro intestinal bleeding
4. Bronchospasm
5. Hypersensitivity
6. Herpes simplex keratitis

Special Precautions while taking Fluticasone
1. Renal failure
2. Hyper tension
3. Hypersensitive to other Non Steroidal Anti Inflammatory Drugs

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Fluticasone
1. Rheumatoid arthritis
2. Osteo arthritis
3. Ankylosing spondylitis
4. Pain in patients with dysmenorrhea.
5. Post operative inflammation of the eye.
6. Migraine
7. Acute gout
Interactions for Fluticasone
None reported.
Typical Dosage for Fluticasone
Oral
Adults- 200-300mg/day in 2-4 divided doses.
Topicaly-0.03% ophthalmic solution. Add 1 drop in every ? hr to the eyes beginning 2-3 hrs before surgery.


Schedule of Fluticasone
H
Storage Requirements for Fluticasone
Store in a sealed container at room a temperature and avoid moisture.
In the case of ophthalmic preparation stored between 15 and 30 degree Celsius.
Effects of Missed Dosage of Fluticasone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fluticasone
Supportive and symptomatic treatment should be given. Empty the stomach by emesis or gastric lavage.

Azelastine

About Azelastine
Second Generation selective H1 Antagonist, mast cell stabilizer, In allergic rhinitis.
Mechanism of Action of Azelastine
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Pharmacokinets of Azelastine
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Onset of Action for Azelastine
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Duration of Action for Azelastine
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Half Life of Azelastine
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Side Effects of Azelastine
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Contra-indications of Azelastine
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Special Precautions while taking Azelastine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Azelastine
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Interactions for Azelastine
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Typical Dosage for Azelastine
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Schedule of Azelastine
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Storage Requirements for Azelastine
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Effects of Missed Dosage of Azelastine
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Effects of Overdose of Azelastine
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Home Delivery for Fluticasone + Azelastine in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluticasone + azelastine and other medicines and health products. Home delivery services for fluticasone + azelastine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fluticasone + azelastine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluticasone + azelastine before they complete the sale. You can get this information while placing the order for fluticasone + azelastine with the pharmacy.

Fluticasone + Azelastine is a generic medicine name and there are several brands available for it. Some of the brands for fluticasone + azelastine might be better known than fluticasone + azelastine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluticasone + azelastine in stock, you can ask for one of the branded alternatives for fluticasone + azelastine.