Terbinafine Pharmacology

Terbinafine

About Terbinafine
A synthetic allylamine derivative, Antifungal.
Mechanism of Action of Terbinafine
Terbinafine is a fungicidal drug. It interfere the conversion of Squalene to Ergosterol by inhibiting the enzyme Squalene epoxidase.This results in accumulation of Squalene in the fungal cells and leads to membrane distortion and death of the Fungus.
Pharmacokinets of Terbinafine
Absorption: It is well absorbed after oral administration.
Distribution: It is distributed in the body in protein bound form. It is concentrated in nail, skin and sebum.
Metabolism: It is metabolised to inactive metabolite in the liver.
Excretion: It is excreted mainly through urine
Onset of Action for Terbinafine
2 weeks
Duration of Action for Terbinafine
N/A
Half Life of Terbinafine
17 hour
Side Effects of Terbinafine
1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastric upset
5. Taste disturbances
6. Visual disturbances
7. Headache
8. Neutropenia
9. Erythema
10. Itching
11. Urticaria
12. Rash
Contra-indications of Terbinafine
1. Hypersensitivity to Terbinafine
Special Precautions while taking Terbinafine
1. Renal Impairment
2. Hepatic dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 12 : Contraindicated
Indications for Terbinafine
1. Tinea pedis
2. Tinea corporis
3. Tinea capitis
4. Tinea cruris
5. Onychomycosis
Interactions for Terbinafine
Cimetidine: Terbinafine clearance is decreased 33%.
Rifampicin: Terbinafine clearance is increased 100%.
Terfenadine: Terbinafine clearance is decreased 16%.
Cyclosprorin: Clearance of cyclospronine increased by 15%.
Typical Dosage for Terbinafine
Adult & Children above age 12: 250 mg daily
Finger nails: 250 mg /day for 11/2 month
Toe nails: 250 mg /day for 3 month
Schedule of Terbinafine
H
Storage Requirements for Terbinafine
The drug should be kept at 30 degree C.Keep away from moisture and light.
Effects of Missed Dosage of Terbinafine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule.
Effects of Overdose of Terbinafine
Give supportive measures and treatment.

Home Delivery for Terbinafine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including terbinafine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for terbinafine and other medicines and health products. Home delivery services for terbinafine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take terbinafine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for terbinafine before they complete the sale. You can get this information while placing the order for terbinafine with the pharmacy.

Terbinafine is a generic medicine name and there are several brands available for it. Some of the brands for terbinafine might be better known than terbinafine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have terbinafine in stock, you can ask for one of the branded alternatives for terbinafine.