- Medicine India
- Generic Medicines
- T
- Pharmacology For Tinidazole + Diloxanide Furoate + Simethicone
Tinidazole + Diloxanide Furoate + Simethicone Pharmacology
Tinidazole + Diloxanide Furoate + Simethicone
About Tinidazole + Diloxanide Furoate + SimethiconeN/AMechanism of Action of Tinidazole + Diloxanide Furoate + SimethiconeN/APharmacokinets of Tinidazole + Diloxanide Furoate + SimethiconeN/AOnset of Action for Tinidazole + Diloxanide Furoate + SimethiconeN/ADuration of Action for Tinidazole + Diloxanide Furoate + SimethiconeN/AHalf Life of Tinidazole + Diloxanide Furoate + SimethiconeN/ASide Effects of Tinidazole + Diloxanide Furoate + SimethiconeN/AContra-indications of Tinidazole + Diloxanide Furoate + SimethiconeN/ASpecial Precautions while taking Tinidazole + Diloxanide Furoate + SimethiconeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tinidazole + Diloxanide Furoate + SimethiconeN/AInteractions for Tinidazole + Diloxanide Furoate + SimethiconeN/ATypical Dosage for Tinidazole + Diloxanide Furoate + SimethiconeN/ASchedule of Tinidazole + Diloxanide Furoate + SimethiconeN/AStorage Requirements for Tinidazole + Diloxanide Furoate + SimethiconeN/AEffects of Missed Dosage of Tinidazole + Diloxanide Furoate + SimethiconeN/AEffects of Overdose of Tinidazole + Diloxanide Furoate + SimethiconeN/ATinidazole
About TinidazoleNitroimidazole antibiotic, Antibacterial, antiprotozoal.Mechanism of Action of TinidazoleTinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. .DNA helix destabilization &strand breakage has been observed.Pharmacokinets of TinidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation &glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for TinidazoleWithin few hoursDuration of Action for Tinidazole16 hoursHalf Life of Tinidazole12 hoursSide Effects of Tinidazole1.Anorexia
2.Bitter taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Fatigue
7.Dry mouth
8.Abdominal distress
9.Headache
10.Dizziness
11.Vertigo
12.Rash
13.Urticaria
14.Angioedema
15.Peripheral neuropathy & CNS effects,
Contra-indications of Tinidazole1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Tinidazole1.Hepatic impairment
2.Alcoholic cirrhosis
3.Obstructive liver diseases
4. Use cautiously along with other hepatotoxic drugs & In visual field changes
5. Avoid alcohol use during therapy
Pregnancy Related InformationUse with caution, but contra indicated in first trimesterOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Tinidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Prophylactic agent after colorectal surgery
6.H. pylori infections
Interactions for TinidazoleAlcohol: Disulfiram like reaction.
Ampicillin, Doxycycline and Cotrimoxaole: Synergism with these agents.Typical Dosage for TinidazoleAmoebiasis:
Adults: 2gm once daily for 3 days
Children: 30 to 50mg/kg/day or 600mg 12hourly for 5 to 10 days
Trichomoniasis & Giardiasis:
600mg once daily for a week or 2gm single dose
Anaerobic bacterial infections:
2 gm followed by 500mg 12 hourly for 5 days
Prophylaxis after colorectal surgery:
2gm single dose before surgery
H. pylori infections:
0.5gm 12hourly for 7 to14 days in triple combination
Schedule of TinidazoleHStorage Requirements for TinidazoleStore at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.Effects of Missed Dosage of TinidazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TinidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. For controlling seizures diazepam & phenytoin may be used Diloxanide Furoate
About Diloxanide FuroateDichloroacetamide derivative, anti-protozoal, Luminal amebicides.Mechanism of Action of Diloxanide FuroateDiloxanide Furoate is a dicloroacetamide derivative which acts as a luminal amoebicide. It exerts its action by directly killing the trophozoites responsible for production of cysts.Pharmacokinets of Diloxanide FuroateAbsorption: Orally well absorbed.
Metabolism: It is metabolized by glucuronide conjugation.
Excretion: Excreted through urine.
Onset of Action for Diloxanide FuroateN/ADuration of Action for Diloxanide FuroateN/AHalf Life of Diloxanide FuroateN/ASide Effects of Diloxanide Furoate1. Flatulence
2. Nausea
3. Itching
4. Urticaria rashes
Contra-indications of Diloxanide FuroateN/ASpecial Precautions while taking Diloxanide Furoate1. Hepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 2 years : ContraindicatedIndications for Diloxanide Furoate1. Mild intestinal Amoebiasis,
2. Asymptomatic cyst passers of Entamoeba histolitica
Interactions for Diloxanide FuroateNo known interaction.Typical Dosage for Diloxanide FuroateAdults: 0.5gm 8hourly for 5 to 10days.
Children (above 2years): 20mg/kg/day in divided doses up to 10days.
Schedule of Diloxanide FuroateHStorage Requirements for Diloxanide FuroateStore in a cool dry place.Protect from heat and light.Keep out of the reach of children.Effects of Missed Dosage of Diloxanide FuroateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diloxanide FuroateGive supportive measures and symptomatic treatment.Simethicone
About SimethiconeOral anti-foaming agent, Silicones, Antiflatulent.Mechanism of Action of SimethiconeThis anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.Pharmacokinets of SimethiconeExcretion- Excreted through feces.Onset of Action for SimethiconeN/ADuration of Action for SimethiconeN/AHalf Life of SimethiconeN/ASide Effects of Simethicone1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Simethicone1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for SimethiconeN/ATypical Dosage for SimethiconeOral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of SimethiconeN/AStorage Requirements for SimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of SimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SimethiconeGive symptomatic and supportive treatment.Home Delivery for Tinidazole + Diloxanide Furoate + Simethicone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tinidazole + diloxanide furoate + simethicone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tinidazole + diloxanide furoate + simethicone and other medicines and health products. Home delivery services for tinidazole + diloxanide furoate + simethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tinidazole + diloxanide furoate + simethicone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tinidazole + diloxanide furoate + simethicone before they complete the sale. You can get this information while placing the order for tinidazole + diloxanide furoate + simethicone with the pharmacy.
Tinidazole + Diloxanide Furoate + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for tinidazole + diloxanide furoate + simethicone might be better known than tinidazole + diloxanide furoate + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tinidazole + diloxanide furoate + simethicone in stock, you can ask for one of the branded alternatives for tinidazole + diloxanide furoate + simethicone.
