Phytomenadione Pharmacology
Phytomenadione
Vitamin K acts as a cofactor in the synthesis of coagulation proteins; prothrombin, factors VII, IX, and X by liver. Vitamin K dependent changes in the final stage of synthesis of these coagulation proteins is gama-carboxylation of glutamate residues of these zymogen proteins and their descarboxy-forms converted in to active forms; which confers on them the capacity to bind Ca2+ and to get bound to the phospholipid surfaces which are essential properties for participation in the coagulation cascade.
2.Cyanosis
3.Impaired taste
4.Haemolysis in G6 PD deficient individuals
5.Headache
6.Dizziness
7.Hypotension
8.Arrhythmias
9.Rapid and weak pulse
10.Diaphoresis
11.Flushing
12.Erythema
13.Urticaria
14.Pruritus
15.Rash
16.Bronchospasm
17.Dyspnea
18.Sense of constriction in the chest
19.Anaphylactic reactions
20.Kernicterus
2.Causes Haemolysis in G6PD deficient individuals and neonates at higher doses
2.For haemorrhagic disease in new born
Mineral oil : May decrease Gl absorption of vitamin K.
10 to 20mg as slow I.V. infusion over 3 to 5minutes or as I.V. infusion over 20 to 30minutes following withdrawal of anticoagulant. Monitor prothrombin levels after 3 hours and repeat the dosage if required.
Maximum daily dose: 40mg
For haemorrhagic disease in new born:
1mg I.M. Repeat if required three times daily. Up to 10mg; if required over 3months based on therapeutic response
Prophylaxis: 1mg I.M.
Home Delivery for Phytomenadione in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including phytomenadione.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for phytomenadione and other medicines and health products. Home delivery services for phytomenadione may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take phytomenadione only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for phytomenadione before they complete the sale. You can get this information while placing the order for phytomenadione with the pharmacy.
Phytomenadione is a generic medicine name and there are several brands available for it. Some of the brands for phytomenadione might be better known than phytomenadione itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phytomenadione in stock, you can ask for one of the branded alternatives for phytomenadione.
