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- Pharmacology For Domperidone + Paracetamol + Tramadol
Domperidone + Paracetamol + Tramadol Pharmacology
Domperidone + Paracetamol + Tramadol
About Domperidone + Paracetamol + TramadolN/AMechanism of Action of Domperidone + Paracetamol + TramadolN/APharmacokinets of Domperidone + Paracetamol + TramadolN/AOnset of Action for Domperidone + Paracetamol + TramadolN/ADuration of Action for Domperidone + Paracetamol + TramadolN/AHalf Life of Domperidone + Paracetamol + TramadolN/ASide Effects of Domperidone + Paracetamol + TramadolN/AContra-indications of Domperidone + Paracetamol + TramadolN/ASpecial Precautions while taking Domperidone + Paracetamol + TramadolN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationNot recommendedChildren Related InformationUse with cautionIndications for Domperidone + Paracetamol + Tramadol1.All painful inflammatory conditions related to musculoskeletal tissue
2.Inflammatory dental condition
3.Dysmenorrhoea
Interactions for Domperidone + Paracetamol + TramadolN/ATypical Dosage for Domperidone + Paracetamol + TramadolN/ASchedule of Domperidone + Paracetamol + TramadolN/AStorage Requirements for Domperidone + Paracetamol + TramadolN/AEffects of Missed Dosage of Domperidone + Paracetamol + TramadolN/AEffects of Overdose of Domperidone + Paracetamol + TramadolN/ADomperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Tramadol
About TramadolA synthetic analogue of codein, Centrally acting Narcotic Analgesic.Mechanism of Action of TramadolIt is centrally acting synthetic drug. Chemically it is not related to the opiates but it act on the Opioid receptors present in the CNS. It has weak agonistic action on mu Opioid receptors, it cause analgesia. Part of this analgesic effect is due to the inhibition of norepinephrine and serotonin reuptake inhibition. However it has agonistic action on mu receptors, respiratory depression and gastrointestinal effects are not prominent.Pharmacokinets of TramadolAbsorption-Absorbed well after oral, intravenous and other parenteral application.
Distribution-Widely distributed in the body, about 20% bound to the plasma protein. It may cross the placenta.
Metabolism-It is metabolized in the liver by O-demethylation; N-demethylation, glucoronidation or sulfation to its metabolites. Mono-O-desmethylate is its active metabolite.
Excretion - Excreted 30% as unchanged form and 60% as its metabolites via urine.
Onset of Action for Tramadol30 to 60 hrsDuration of Action for Tramadol8 to 12 hrsHalf Life of TramadolN/ASide Effects of Tramadol1. Dizziness
2. Weakness
3. Headache
4. Anxiety
5. Agitation
6. Drowsiness
7. Blurred vision
8. Stomach upset
9. Vomiting
10. Diarrhea
11. Constipation
12. Itching
13. Sweating
14. Flushing
15. Dry mouth
Contra-indications of Tramadol1. Hypersensitivity to this drug
2. Acute alcoholic intoxification
3. Hypnotics
4. With centrally acting analgesics
5. With psychotropic drug
6. With Opioid drug
Special Precautions while taking Tramadol1. Head injury
2. Acute abdominal conditions
3. Seizures
4. Respiratory depression
5. Renal failure
6. Hepatic failure
7. Physical dependence on Opioids
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Tramadol1. Post operative pain
2. Arthralgia
3. Musculoskeletal pain
4. Low back pain
5. Pain associated with other reasons
Interactions for TramadolCarbamazepine: A significant increase in Tramadol metabolism.
Hypnotics, Tranquilizers and other CNS depressants: Sedative effects potentiated.
MAOIs: Fatal interaction occurs.
Opioid analgesics like Buprenorphine, Butorphanol and Pentazocine: May precipitate withdrawl symptoms.
Tranquilizers: Analgesia potentiated.Typical Dosage for TramadolOral-
Adults - 50 to 100mg every 4 to 6 hrs or twice daily.
Intravenous-
50 to 100 mg given every 4 to 6 hrs.
Rectal-
100 mg suppository 4 times daily.
Schedule of TramadolN/AStorage Requirements for TramadolStore at room temperature in a tightly closed container and away from heat & moisture. Keep out of reach of children.Effects of Missed Dosage of TramadolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TramadolEstablish artificial respiratory exchange. Naloxone administration cannot relieve all the symptoms produced by tramadol. Haemodialysis can remove a small fraction of drug from the body. Provide symptomatic and supportive treatment.Home Delivery for Domperidone + Paracetamol + Tramadol in Your City
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Domperidone + Paracetamol + Tramadol is a generic medicine name and there are several brands available for it. Some of the brands for domperidone + paracetamol + tramadol might be better known than domperidone + paracetamol + tramadol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have domperidone + paracetamol + tramadol in stock, you can ask for one of the branded alternatives for domperidone + paracetamol + tramadol.
