Fludrocortisone acetate Pharmacology

Fludrocortisone acetate

About Fludrocortisone acetate
Systemic adrenocortical steroid (mineral corticoid), Organofluoride derivative, Mineral corticoid replacement therapy
Mechanism of Action of Fludrocortisone acetate
It is a potent mineralocorticoid also having some glucocorticoid action. The drug exerts it`s pharmacological action; in adrenocortical insufficiency by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It enhances the sodium reabsorption in the distal tubule of the kidney.
Pharmacokinets of Fludrocortisone acetate
Absorption: Well absorbed orally
Distribution: Distributed in to muscle, liver, kidney, skin, and intestine. It crosses the placenta and also secreted in breast milk
Metabolism: Metabolized in liver in to inactive metabolites by glucuronide and sulfate conjugation.
Excretion: Metabolites and small amount of unchanged drug are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Fludrocortisone acetate
Duration of Action for Fludrocortisone acetate
1 to 2 days
Half Life of Fludrocortisone acetate
18 to 36 hours
Side Effects of Fludrocortisone acetate
1. Hypertension
2. Fluid retention
3. Oedema
4. Hypokalaemia
5. Alkalosis
6. Cardiac hypertrophy
7. Heart failure
8. Diaphoresis
9. Urticaria
10. Rashes
Contra-indications of Fludrocortisone acetate
1. Hypersensitivity to the drug
2. Hypertension
3. Hyperalbuminaemia
4. Systemic fungal infections
Special Precautions while taking Fludrocortisone acetate
1. Hypothyroidism
2. Ocular herpes simplex
3. Cirrhosis
4. Psychosis
5. Emotional instability
6. Epilepsy
7. Congestive heart failure
8. Recent intestinal anastamoses
9. Non specific ulcerative colitis
10. Diverticulitis
11. Renal impairment
12. Peptic ulcer
13. Myasthenia gravis
14. Osteoporosis
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Fludrocortisone acetate
1. Partial replacement therapy with adrenocortical insufficiency
2. Salt-losing adrenogenital hyperplasia
3. Postural hypotension in diabetic patients
4. Orthostatic hypotension.
Interactions for Fludrocortisone acetate
Typical Dosage for Fludrocortisone acetate
Oral: 50 to 200mcg/day
Children: 50 to 100mcg/day
Replacement therapy with adrenocortical insufficiency: 0.05 to 0.3mg along with glucocorticoids
Postural hypotension in diabetic patients, Orthostatic hypotension: 100mcg to 400mcg/day
Schedule of Fludrocortisone acetate
Storage Requirements for Fludrocortisone acetate
Store at room temperature below 25 degree C.
Effects of Missed Dosage of Fludrocortisone acetate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fludrocortisone acetate
Correct fluid and electrolyte imbalance and provide supportive and symptomatic treatment.

Home Delivery for Fludrocortisone acetate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fludrocortisone acetate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fludrocortisone acetate and other medicines and health products. Home delivery services for fludrocortisone acetate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fludrocortisone acetate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fludrocortisone acetate before they complete the sale. You can get this information while placing the order for fludrocortisone acetate with the pharmacy.

Fludrocortisone acetate is a generic medicine name and there are several brands available for it. Some of the brands for fludrocortisone acetate might be better known than fludrocortisone acetate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fludrocortisone acetate in stock, you can ask for one of the branded alternatives for fludrocortisone acetate.