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- Pharmacology For Glipizide
GlipizideAbout GlipizideSecond generation sulfonylurea, Pyrazine derivative, Medium-to-long acting Oral Antidiabetic Agent.Mechanism of Action of GlipizideIt is a potent antidiabetic drug which exerts it`s action by increasing insulin release from the pancreas and by improving glucose tolerance. It acts on the "sulfonylurea receptors" on pancreatic ?-cell membrane and reduces conductance of ATP sensitive K+ channels and thus causes depolarization. This enhances Ca2+ influx and degranultion and thus increases insulin secretion rate at any glucose concentration. It primarily increases 2nd phase insulin secretion and has little effect on 1st phase. It also slows hepatic degradation of insulin and minor action of reducing glucagon release and increasing Somatostatin release. It also exerts extrapancreatic action; by sensitizing the target tissues such as liver to insulin action. It increases the number of insulin receptors and through a post receptor action improving translation of receptor activation.Pharmacokinets of GlipizideAbsorption: Well absorbed orally.
Distribution: Distributed in a protein bound form.
Metabolism: Completely metabolized in to inactive metabolites in liver.
Excretion: Excreted mainly through urine and also through faeces as metabolites.
Onset of Action for Glipizide60 to 90 minutesDuration of Action for Glipizide12 to 18 hoursHalf Life of Glipizide3 to 5 hoursSide Effects of Glipizide1. Hypoglycemia
8. Hypersensitivity reactions
12. Transient leucopenia
Contra-indications of Glipizide1. Hypersensitivity to the drug
2. Diabetic ketoacidosis
3. Diabetic coma
4. Renal impairment
5. Hepatic impairment
6. Juvenile diabetes mellitus
Special Precautions while taking Glipizide1. Malnourished and deliberate individuals
2. Strenous exercise and irregular meals may leads to hypoglycemia
3. Hepatic diseases
4. Renal diseases
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Glipizide1. Non insulin dependent diabetes mellitus.Interactions for GlipizideHypoglycaemic effect of glipizide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers.
Hypoglycemic effect of glipizide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers.
Charcoal: Reduces the absorption of glipizide thus reducing its efficacy or toxicity.
Digitalis glycosides: Coadministration results in increased digitalis serum levels.
Typical Dosage for GlipizideOral: Starts with 2.5 to 5mg daily; 30 minutes prior to breakfast. Adjust the dosage by increments of 2.5 to 5mg at weekly intervals up to 15mg/day as required.Schedule of GlipizideN/AStorage Requirements for GlipizideStore at room temperature at a range of 15 to 30 degree C. in a well closed container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of GlipizideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GlipizideMild hypoglycemia can be treated with oral glucose and dosage adjustment. It there is loss of consciousness or neurological findings the patient should receive rapid injection of dextrose 50%; followed by continuous infusion of dextrose 10% at a rate to maintain blood glucose levels greater than 100mg/dl. Monitor patient for 24 to 48 hours.
Home Delivery for Glipizide in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including glipizide.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glipizide and other medicines and health products. Home delivery services for glipizide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take glipizide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for glipizide before they complete the sale. You can get this information while placing the order for glipizide with the pharmacy.
Glipizide is a generic medicine name and there are several brands available for it. Some of the brands for glipizide might be better known than glipizide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glipizide in stock, you can ask for one of the branded alternatives for glipizide.