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- Pharmacology For Nateglinide
NateglinideAbout NateglinideMeglitinide Derivative, Oral Antidiabetic Agent.Mechanism of Action of NateglinideIt is a quick and short acting antidiabetic drug which exerts it`s action by stimulating insulin release from ?-cells of pancreas. It acts by binding to sulfonylurea receptor and to other distinct receptors and closes ATP dependent potassium channels and thus causes depolarization. This depolarization of pancreatic ? cells causes opening of Ca channels and increased Ca influx which induces insulin secretion.Pharmacokinets of NateglinideAbsorption: Well absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in to active metabolites, Excretion: Excreted mainly through urine as metabolites.Onset of Action for NateglinideN/ADuration of Action for Nateglinide2 to 3 hoursHalf Life of Nateglinide1.5 hoursSide Effects of Nateglinide1.Flu like symptoms
8.Increased uric acid
13.Upper respiratory tract infections
15.Mild hypoglycaemiaContra-indications of Nateglinide1. Hypersensitivity to the drug
2. Type-1 diabetes mellitus
3. Diabetic ketoacidosisSpecial Precautions while taking Nateglinide1.Hepatic impairment
2.Malnourished and deliberate individuals
3.After severe exercise
4.Along with alcohol
5.Along with other glucose lowering drugs
6.Loss of control of blood glucose may occur with drug when patient is exposed to stress such as fever, trauma, infection, or surgery. In such situations stop the Nateglinide and administer insulin
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Nateglinide1. Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise)Interactions for NateglinideNsaids, salicylates, MAOIs, and non selective beta-adrenergic blocking agents: May potentiate the hypoglycaemic effects.
Thiazides, corticosteroids, thyroxine and sympathomimetics: May reduce the hypoglycaemic effects.
Typical Dosage for NateglinideOral: Starts with 60mg thrice daily; taken 10 to 30 minutes before each main meals. Increases the dose based on patient`s response.
Maximum dose: 180mg thrice daily.
Schedule of NateglinideN/AStorage Requirements for NateglinideStore at room temperature at a range of 15 to 30 degree C.in a well closed container. Protect from moisture. Keep out of reach of children.Effects of Missed Dosage of NateglinideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NateglinideProvide symptomatic treatment and supportive measures. Treat mild hypoglycaemia with glucose and also; dosage or meal pattern adjustment. Closely monitor patient for at least 24 to 48 hours. Treat severe hypoglycaemia with neurological manifestations with I.V. dextrose 50% solution followed by a continuous infusion of glucose 10%solution. Carefully monitor blood sugar levels.
Home Delivery for Nateglinide in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nateglinide.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nateglinide and other medicines and health products. Home delivery services for nateglinide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take nateglinide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nateglinide before they complete the sale. You can get this information while placing the order for nateglinide with the pharmacy.
Nateglinide is a generic medicine name and there are several brands available for it. Some of the brands for nateglinide might be better known than nateglinide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nateglinide in stock, you can ask for one of the branded alternatives for nateglinide.