Insulin Neutral Pharmacology
Insulin stimulates glucose transport across cell membrane by ATP dependent translocation of glucose transporters GLUT1 and GLUT4 to the plasma membrane and by increasing their activity. Insulin promotes the expression of genes directing synthesis of glucose transporters. It also regulates genes for a large number of enzymes and carriers primarily through muscle action potential (MAP) kinases
Insulin causes increased production of glucokinase improves intracellular utilization of glucose. It also stimulates glycogen synthetase and enhances glycogen synthesis and inhibits phosphorylase and thus decreases glycogenolysis in liver. Insulin reduces synthesis of phosphoenol pyruvate carboxykinase and inhibits gluconeogenesis. It inhibits lipolysis in adipose tissue and favours triglyceride synthesis. Insulin increases clearance of VLDL and chylomicrons by stimulating transcription of vascular endothelial lipoprotein lipase. Insulin improves synthesis of proteins from amino acids and prevents breakdown of proteins.
Distribution: It is widely distributed throughout the body.
Metabolism: It is metabolized in liver, muscles, and kidney.
Peak action: 1-3 hours.
2. Lipodystrophy at injection site
4. Insulin resistance
2. Along with other drugs
3. Along with alcohol
6. Hepatic impairment
7. Renal impairment
8. Rotate the injection site
2. Diabetic ketoacidosis
3. Pregnant diabetics
4. Stressful conditions like surgery, labour
5. For dose titration in type I diabetes
Drugs which increase hypoglycaemic effect of insulin : Alcohol, anabolic steroids, beta-blockers, clofibrate, guanethidine, MAO inhibitors, phenylbutazone, salicylates, tetracyclines.
S.C., I.V.: Adults and children: 0.5 to 1.2 U/kg/day. Adjust dosage based on blood glucose level.
Diabetic ketoacidosis: 0.15U/kg I.V. loading dose followed by 0.1U/kg/hour as a continuous infusion. Decrease rate of infusion when plasma insulin level reaches 300mg/dl. Start infusion of D5W separately from the Insulin infusion when plasma glucose level reaches 250mg/dl. Half hours before stopping infusion administer a dose of intermediate acting Insulin.
Home Delivery for Insulin Neutral in Your City
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Insulin Neutral is a generic medicine name and there are several brands available for it. Some of the brands for insulin neutral might be better known than insulin neutral itself. If the pharmacy that's willing to deliver medicines to your home doesn't have insulin neutral in stock, you can ask for one of the branded alternatives for insulin neutral.