Insulin Glargine Pharmacology
Insulin stimulates glucose transport across cell membrane by ATP dependent translocation of glucose transporters GLUT1 and GLUT4 to the plasma membrane and by increasing their activity. Insulin promotes the expression of genes directing synthesis of glucose transporters. It also regulates genes for a large number of enzymes and carriers primarily through muscle action potential (MAP) kinases
Insulin causes increased production of glucokinase improves intracellular utilization of glucose. It also stimulates glycogen synthetase and enhances glycogen synthesis and inhibits phosphorylase and thus decreases glycogenolysis in liver. Insulin reduces synthesis of phosphoenol pyruvate carboxykinase and inhibits gluconeogenesis. It inhibits lipolysis in adipose tissue and favours triglyceride synthesis. Insulin increases clearance of VLDL and chylomicrons by stimulating transcription of vascular endothelial lipoprotein lipase. Insulin improves synthesis of proteins from amino acids and prevents breakdown of proteins.
Distribution: It is widely distributed throughout the body
Metabolism: It is metabolized in liver, muscles, and kidney.
Peak action: 10-30 hours.
2. Lipodystrophy at injection site
4. Insulin resistance
4. Should not administer intravenously
5. Should not be mixed with other Insulins or diluted
2. Along with other drugs
3. Along with alcohol
4. Rotate the injection site
5. Renal impairment
6. Hepatic impairment
Children (below 6 years) : Contraindicated
2. Type II diabetes mellitus
Drugs which increase hypoglycaemic effect of insulin : Alcohol, anabolic steroids, beta-blockers, clofibrate, guanethidine, MAO inhibitors, phenylbutazone, salicylates, tetracyclines.
Home Delivery for Insulin Glargine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including insulin glargine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for insulin glargine and other medicines and health products. Home delivery services for insulin glargine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take insulin glargine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for insulin glargine before they complete the sale. You can get this information while placing the order for insulin glargine with the pharmacy.
Insulin Glargine is a generic medicine name and there are several brands available for it. Some of the brands for insulin glargine might be better known than insulin glargine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have insulin glargine in stock, you can ask for one of the branded alternatives for insulin glargine.