Conjugated Oestrogens Pharmacology

Conjugated Oestrogens

About Conjugated Oestrogens
Estrogen Derivative, Hormone replacement therapy(commonly in post menopause).
Mechanism of Action of Conjugated Oestrogens
The drug exerts it`s pharmacological action by binding to specific nuclear estrogen receptors present in target cells and regulating protein synthesis and thus producing desired therapeutic effects. Estrogen receptors are found in female sex organs, breast, pituitary, liver, bone, blood vessels, heart, CNS, hormone sensitive breast carcinoma cells, hormone responsive prostate carcinoma cells. Agonist binding to ligand binding domain of these receptors results in receptor dimerization and interaction with "estrogen response elements" of target genes and thus promotes gene transcription; through certain coactivator proteins which ultimately leads to modification of protein synthesis.
It causes growth and development of female sex organs, maintains proper female sexual functioning. It exerts week anabolic action, and also maintain bone mass primarily by preventing bone resorption. It inhibits osteoclast pit formation and increases the expression of bone matrix proteins and also improves lipid profile (rises HDL and lowers LDL levels). It inhibits growth of hormone responsive carcinoma cells in prostate cancer and certain breast cancer.
Pharmacokinets of Conjugated Oestrogens
Absorption: Well absorbed after oral, parenteral, and vaginal administration. Distribution: Extensively distributed in the body with highest levels in the fatty tissue. About 50% to 80% is plasma protein bound. Metabolism: Metabolized primarily in liver by glucuronide and sulfate conjugation. Excretion: Excreted through urine as sulfate or glucuronide conjugates

Onset of Action for Conjugated Oestrogens
Duration of Action for Conjugated Oestrogens
Half Life of Conjugated Oestrogens
Side Effects of Conjugated Oestrogens
1.Breakthrough bleeding
2.Breast tenderness
3.Breast enlargement
4.Gastrointestinal disturbances
14.Increased risk of endometrial cancer
15.Increased of breast cancer
16.Cholestatic jaundice
17.Hepatic adenoma.
Contra-indications of Conjugated Oestrogens
2.Thromboembolic disorders
3.Estrogen dependent neoplasia
4.Undiagnosed genital bleeding
5.Estrogen dependent breast carcinoma
6.Hepatic impairment
7.Endometrial hyperplasia
Special Precautions while taking Conjugated Oestrogens
3.Heart failure
5.Diabetes mellitus
6.Renal impairment
7.Fibrocystic disease of breast
8.Abnormal mammographic findings
9.Cerebrovascular diseases
10.Coronary artery diseases
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Conjugated Oestrogens
1.Female hypogonadism
3.Primary ovarian failure
4.Vasomotor menopausal symptoms
5.Estrogen replacement
6.Atrophic vaginitis
7.Abnormal uterine bleeding (hormonal imbalance)
8.Palliative treatment of certain breast cancer
9.Palliative treatment of prostatic cancer
Interactions for Conjugated Oestrogens
Typical Dosage for Conjugated Oestrogens
Oral: 0.625 to 1.25mg/day
Female hypogonadism: 0.3 to 0.625mg/day in cycles of 21 days on and 7days off. Increases the dose as required
Osteoporosis: 0.625mg/day given continuously or cyclically as 25days on and 5 days off.
Primary ovarian failure: Starts with1.25mg/day in cycles of 21 days on and 7days off. Adjust the dosage as required
Vasomotor menopausal symptoms: 0.625mg/day given continuously or cyclically as 25days on and 5 days off.
Estrogen replacement: 0.625mg/day
Atrophic vaginitis: 0.3mg to 1.25mg/day depending up on the patient`s response.
Palliative treatment of prostatic cancer: 1.25 to 2.5mg thrice daily
Palliative treatment of breast cancer: 10mg thrice daily for 3 months.
I.V. or I.M.:
Abnormal uterine bleeding: 20 to 25mg I.M. or as slow I.V. administration. Repeat 2 to 4 times daily if required.
Vaginal cream:
Atrophic vaginitis: ? to 2g/day intravaginally depending up on the severity of the condition (Each one gram contains 0.625mg of drug)
Schedule of Conjugated Oestrogens
Storage Requirements for Conjugated Oestrogens
Store at controlled room temperature at a range of 15 to 30 degreeC. Injection preparation should be stored at a temperature range of 2 to 80C.
Effects of Missed Dosage of Conjugated Oestrogens
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Conjugated Oestrogens
Provide symptomatic treatment and supportive care.

Home Delivery for Conjugated Oestrogens in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including conjugated oestrogens.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for conjugated oestrogens and other medicines and health products. Home delivery services for conjugated oestrogens may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take conjugated oestrogens only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for conjugated oestrogens before they complete the sale. You can get this information while placing the order for conjugated oestrogens with the pharmacy.

Conjugated Oestrogens is a generic medicine name and there are several brands available for it. Some of the brands for conjugated oestrogens might be better known than conjugated oestrogens itself. If the pharmacy that's willing to deliver medicines to your home doesn't have conjugated oestrogens in stock, you can ask for one of the branded alternatives for conjugated oestrogens.