Testosterone Pharmacology


About Testosterone
A steroid hormone, Androgen.
Mechanism of Action of Testosterone
Testosterone and it`s reduced form; dihydrotestosterone binds with cytoplasmic testosterone receptors in androgen responsive organs and tissues and forms hormone receptor complex. This hormone-receptor complex binds with DNA and enhances DNA transcription and formation of mRNA which ultimately leads to modification of protein synthesis. It promotes growth and development of male sex organs and secondary sexual characters and maintains proper sexual functioning. It also exerts anabolic effect on skeleton and skeletal muscles and accelerates erythropoiesis. It also excerts inhibitory, antiestrogenic effects on hormone responsive breast tumors and metastases.
Pharmacokinets of Testosterone
Absorption: It is inactive orally and administered parenterally, Distribution: Widely distributed in a highly plasma protein bound form, Metabolism: Metabolized in liver in to several metabolites which further undergoes glucuronide and sulfate conjugation. Excretion: Excreted mainly through urine as metabolites
Onset of Action for Testosterone
Duration of Action for Testosterone
Half Life of Testosterone
10 to 100minutes
Side Effects of Testosterone
5.Impaired glucose tolerance
6.Altered thyroid function tests
7.Retention of water
8.Weight gain
10.Abnormal liver function tests
11.Cholestatic jaundice
12.Hepatic carcinoma
14.Hypo estrogenic effects in females
18.Menstrual irregularities
19.Androgenic effects in women
21.Excessive hormonal effects in men
22.Premature epiphyseal closure
25.Increased libido
26.Testicular atrophy
28.Allergic manifestations
29.Pin and induration at injection site
33.Sleep apnea
Contra-indications of Testosterone
1.Prostate cancer
2.Male breast cancer
3.Overt cardiac failure
4.Severe hepatic impairment
5.Severe renal impairment
Special Precautions while taking Testosterone
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disorders
6.Discontinue Transdermal system if oedema occurs
7.Women of child bearing age
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Testosterone
1.Male hypogonadism
2.Delayed puberty in males
4.Post partum breast pain
5.Carcinoma of breast
6.Maintain positive nitrogen balance
7.Post pubertal cryptorchidism
Interactions for Testosterone
Oral hypoglycemic agents and Insulin: Effect of these agents potentiated.
Corticosteroids: Tendency towards oedema enhanced. Use with caution in patients with hepatic or cardiac disease.
Lab tests: May decrease levels of thyroxine binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 & T4. Free thyroxine levels remain unchanged.
Typical Dosage for Testosterone
Male hypogonadism:
Testosterone propionate: 25mg twice weekly to thrice weekly or 50mg at two week intervals.
Testosterone enanthate or cypionate: 50mg to 400mg at every 2 to 4 weeks.
Delayed puberty in males:
Testosterone propionate: 25mg to 50mg twice weekly to thrice weekly for up to 6months.
Testosterone enanthate or cypionate: 50mg to 200mg at every 2 to 4 weeks for up to 6months.
Post partum breast pain: 25 to 50mg/day for 3 to 4days.
Carcinoma of breast:
Testosterone: 100mg thrice weekly
Testosterone propionate: 50 to 100mg thrice weekly.
Testosterone enanthate or cypionate: 200mg to 400mg at every 2 to 4 weeks.
Post pubertal cryptorchidism:
Testosterone propionate: 25mg twice weekly to thrice weekly
Testosterone enanthate:
Male hypogonadism: 250mg at 2 to 3 week intervals
Maintenance dosage: 250mg at 3to 4 week intervals.
Impotence: 100mg; repeat after a week. In infertility treatment should be continued for 3 months and repeat if required after a period of several weeks.
Andropause, Gynaecomastia: Apply 5g gel once daily
Male hypogonadism, Delayed puberty: Apply 2.5g gel daily
Androderm: 5mg daily on dry area of skin on back, upper arm, thigh, abdomen. Do not apply to scrotum.
Testoderm: 6mg daily apply to scrotal area.
Schedule of Testosterone
Storage Requirements for Testosterone
Store at room temperature below 25 degree C
Effects of Missed Dosage of Testosterone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Testosterone
Provide symptomatic treatment and supportive measures

Home Delivery for Testosterone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including testosterone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for testosterone and other medicines and health products. Home delivery services for testosterone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take testosterone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for testosterone before they complete the sale. You can get this information while placing the order for testosterone with the pharmacy.

Testosterone is a generic medicine name and there are several brands available for it. Some of the brands for testosterone might be better known than testosterone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have testosterone in stock, you can ask for one of the branded alternatives for testosterone.