Somatropin Pharmacology


About Somatropin
Synthetic human growth hormone, Treatment of growth hormone deficiency.
Mechanism of Action of Somatropin
It is a purified growth hormone (GH) of recombinant DNA origin that stimulates skeletal, linear bone, muscle, and organ growth. It promotes growth by inducing hyperplasia. It acts on cell surface receptors present on all cells. Binding of GH molecule to the extracellular domain of two growth hormone receptors induces their dimerization and activates intracellular domain through a single transmembrane peptide segment. The activated intracellular domain associated with cytoplasmic Jak2 tyrosin-protein kinase and phosphorylates relevant proteins which carry out various actions. The growth hormone also exerts indirect actions through elaboration of peptides called somatomedins or Insulin like growth factors (IGF-1, IGF-2) which are extracellular mediators of GH response. It causes proportionate increase in size and mass of all parts and promotes retention of nitrogen and other tissue constituents, formation of more protoplasm. It maintains positive nitrogen balance.

Pharmacokinets of Somatropin
Absorption: Absorbed from injection site as human GH Distribution: Distributed in to highly perfused organs such as liver and kidney, Metabolism: Metabolized in liver and returned to systemic circulation as amino acids.
Onset of Action for Somatropin
Duration of Action for Somatropin
12 to 48hours
Half Life of Somatropin
Side Effects of Somatropin
1. Headache
2. Weakness
3. Oedema
4. Hypothyroidism
5. Hyperglycaemia (mild)
6. Salt and water retention
7. Pain at injection site
8. Lipodystrophy

Contra-indications of Somatropin
1. Active neoplasia
2. After epiphyseal fusion
3. Intracranial lesion
4. After renal transplantation
Special Precautions while taking Somatropin
1. Hypothyroidism
2. Diabetes mellitus
3. Papilloedema
4. Deficiency of other pituitary hormones
5. History of malignant disease
5. Intracranial hypertension
6. Slipped epiphyses of the hip
Pregnancy Related Information
Old Age Related Information
May be used
Breast Feeding Related Information
Children Related Information
Indications for Somatropin
1. Growth failure in children due to deficiency of endogenous growth hormone
2. Growth failure due to renal failure
3. Turner`s syndrome
Interactions for Somatropin
Typical Dosage for Somatropin
S.C., I.M.: 0.1 i.u./kg/day or more; depending up on the individual needs. Taken as 6 to 7 divided S.C. injection/day 3 times a week.
Turner`s syndrome: 0.09 to 0.14 i.u./kg/day
Renal failure: 0.15 i.u./kg/day by S.C. injection.
Schedule of Somatropin
Storage Requirements for Somatropin
Store at a temperature range of 2 to 8 degree C.
Effects of Missed Dosage of Somatropin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Somatropin
Provide symptomatic treatment and supportive measures.

Home Delivery for Somatropin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including somatropin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for somatropin and other medicines and health products. Home delivery services for somatropin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take somatropin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for somatropin before they complete the sale. You can get this information while placing the order for somatropin with the pharmacy.

Somatropin is a generic medicine name and there are several brands available for it. Some of the brands for somatropin might be better known than somatropin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have somatropin in stock, you can ask for one of the branded alternatives for somatropin.