Miconazole + Clobetasone butyrate Pharmacology

Miconazole + Clobetasone butyrate

About Miconazole + Clobetasone butyrate
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Mechanism of Action of Miconazole + Clobetasone butyrate
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Pharmacokinets of Miconazole + Clobetasone butyrate
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Onset of Action for Miconazole + Clobetasone butyrate
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Duration of Action for Miconazole + Clobetasone butyrate
N/A
Half Life of Miconazole + Clobetasone butyrate
N/A
Side Effects of Miconazole + Clobetasone butyrate
N/A
Contra-indications of Miconazole + Clobetasone butyrate
N/A
Special Precautions while taking Miconazole + Clobetasone butyrate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
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Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Miconazole + Clobetasone butyrate
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Interactions for Miconazole + Clobetasone butyrate
N/A
Typical Dosage for Miconazole + Clobetasone butyrate
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Schedule of Miconazole + Clobetasone butyrate
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Storage Requirements for Miconazole + Clobetasone butyrate
N/A
Effects of Missed Dosage of Miconazole + Clobetasone butyrate
N/A
Effects of Overdose of Miconazole + Clobetasone butyrate
N/A

Miconazole

About Miconazole
An imidazole derivative, Broad spectrum Antifungal.
Mechanism of Action of Miconazole
Miconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis
Pharmacokinets of Miconazole
Absorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.
Onset of Action for Miconazole
N/A
Duration of Action for Miconazole
N/A
Half Life of Miconazole
1 day
Side Effects of Miconazole
1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis
Contra-indications of Miconazole
1.Hypersensitivity to Miconazole and other Azole antifungals
Special Precautions while taking Miconazole
1.Hepatic dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Miconazole
1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitis
Interactions for Miconazole
Benzoyl peroxide: Antibacterial synergism.
Typical Dosage for Miconazole
Adult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days

CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part

Schedule of Miconazole
H
Storage Requirements for Miconazole
The drug should be stored at 15 - 30 degree C.
Effects of Missed Dosage of Miconazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Miconazole
Give supportive measures and treatment.

Clobetasone butyrate

About Clobetasone butyrate
A new corticosteroid, Anti inflammatory.
Mechanism of Action of Clobetasone butyrate
Clobetasone is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation on the inflamed area. Thus inhibiting inflammatory mediators and other actions Clobetasone are used for anti-inflammatory conditions.

Pharmacokinets of Clobetasone butyrate
Absorption: Clobetasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used and the epidermal barrier
Onset of Action for Clobetasone butyrate
N/A
Duration of Action for Clobetasone butyrate
N/A
Half Life of Clobetasone butyrate
N/A
Side Effects of Clobetasone butyrate
1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers Caused by application around eyelids and surrounding skin
Contra-indications of Clobetasone butyrate
1.Hypersensitivity to Clobetasone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Clobetasone butyrate
1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children, 6. For external use only
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Clobetasone butyrate
Skin disorders.
1.Otitis externa
2.Eczema
3.Dermatitis
4.Photodermatitis
5.Intertrigo (Inflammation in the skin folds)
6.Seborrheic dermatitis
7.Allergy or irritant dermatitis
8.Dermatoses (secondary infected)
9.Reaction to insect bite and stings
Interactions for Clobetasone butyrate
N/A
Typical Dosage for Clobetasone butyrate
Topical: Clobetasone 0.05 % cream is used. Apply the medicament thinly and evenly on the affected area 3- 4 times daily. Maximum drug100 g / week
Schedule of Clobetasone butyrate
N/A
Storage Requirements for Clobetasone butyrate
Store at room temperature. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Clobetasone butyrate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clobetasone butyrate
Give supportive measures and symptomatic treatment.

Home Delivery for Miconazole + Clobetasone butyrate in Your City

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Miconazole + Clobetasone butyrate is a generic medicine name and there are several brands available for it. Some of the brands for miconazole + clobetasone butyrate might be better known than miconazole + clobetasone butyrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have miconazole + clobetasone butyrate in stock, you can ask for one of the branded alternatives for miconazole + clobetasone butyrate.