Triamcinolone acetonide Pharmacology

Triamcinolone acetonide

About Triamcinolone acetonide
A synthetic glucocorticoid, Topical anti-inflammatory(steroidal).
Mechanism of Action of Triamcinolone acetonide
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Triamcinolone acetonide
Absorption: Triamcinolone acetonide is absorbed after topical application. Distribution: It is distributed mainly in protein bound form. Metabolism: It is metabolized primarily in the liver. Excretion: It is excreted by the kidneys and small amount is excreted through bile also.
Onset of Action for Triamcinolone acetonide
Duration of Action for Triamcinolone acetonide
Half Life of Triamcinolone acetonide
Side Effects of Triamcinolone acetonide
7.Acneiform eruptions
10.Secondary infection
11.Skin atrophy
Contra-indications of Triamcinolone acetonide
Hypersensitivity to Triamcinolone acetonide
Special Precautions while taking Triamcinolone acetonide
1.Occlusive dressings
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Triamcinolone acetonide
1. Inflammations of corticosteroid-responsive dermatoses
2. Treatment of skin disorders: Dermatitis, Psoriasis
Interactions for Triamcinolone acetonide
Typical Dosage for Triamcinolone acetonide
Topical application: Apply the cream on the affected area 2-4 times daily; depending on the severity of the condition.
Schedule of Triamcinolone acetonide
Storage Requirements for Triamcinolone acetonide
Store at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.
Effects of Missed Dosage of Triamcinolone acetonide
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Triamcinolone acetonide
Provide symptomatic treatment and supportive measures.

Home Delivery for Triamcinolone acetonide in Your City

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Triamcinolone acetonide is a generic medicine name and there are several brands available for it. Some of the brands for triamcinolone acetonide might be better known than triamcinolone acetonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have triamcinolone acetonide in stock, you can ask for one of the branded alternatives for triamcinolone acetonide.