Prednicarbate Pharmacology
Prednicarbate
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
2. Burning
3. Itching
4. Irritation
5. Atrophy (Dermal changes)
6. Telangiectasia
7. Striae
8. Hypopigmentation
9. Contact dermatitis
10. Perioral dermatitis
11. Stinging
12. Cataract, Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne
16. Folliculitis,
2. Acne vulgaris
3. Acne Rosacea
4. Tuberculosis infection of the skin
5. Perioral dermatitis
6. Viral, fungal or bacterial primary infections
7. Ulcers
2. Prolonged use
3. Psoriasis
4. Avoid contact with eyes
5. Avoid occlusive dressing
6. Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments
8. Use caution on areas where the skin creases, such as armpits, knees, and elbows
9. For external use only
NEONATES: Contraindicated
2. Eczema
3. Seborrheic dermatitis
4. Dermatoses (secondary infected)
5. Atopic dermatitis
6. Intertrigo
Home Delivery for Prednicarbate in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including prednicarbate.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for prednicarbate and other medicines and health products. Home delivery services for prednicarbate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take prednicarbate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for prednicarbate before they complete the sale. You can get this information while placing the order for prednicarbate with the pharmacy.
Prednicarbate is a generic medicine name and there are several brands available for it. Some of the brands for prednicarbate might be better known than prednicarbate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have prednicarbate in stock, you can ask for one of the branded alternatives for prednicarbate.
